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  • 27 February 2016 at 8:07 am #12793
    Avatar photoHit The Road Jack
    • Topics: 4
    • Replies: 24
    • Total: 28
    • Treatment Warrior
    • ★★★
    @hit-the-road-jack

    Hi

    Hello everyone, I’m new to this site. I’ve noticed there have been posts recommending to avoid I’d some fruits ie grape fruit etc..I just had a Cup of licorice tea and as an after thought decided to check if it potentially inhibited CYP3A4..I think it does..my concern is has this one cup of licorice
    Damaged my chances for a sussessful outcome re treatment..

    It’s only early days for me re commencing treatment ..Feeling worried .. I’m due to take my 3rd dose of Sol/dac tonight

    Any advise would be appreciated :)

    Tx naive. GT3a
    Female
    Diagnosed 1996

    Start 25/2/16
    VL 62700
    F0
    hb 141
    ALT 36
    ALP 81

    4 week test
    VL UND
    ALT 18
    ALP 70

    Additional 4 weeks Tx
    Start 19.5.16

    27 February 2016 at 8:17 am #12794
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    I’m no Dr, but I wouldn’t think it has harmed your chances. Especially since your intake of tea and your dose is staggered.

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    27 February 2016 at 8:27 am #12795
    Avatar photoHit The Road Jack
    • Topics: 4
    • Replies: 24
    • Total: 28
    • Treatment Warrior
    • ★★★
    @hit-the-road-jack

    Appreciate your speedy/helpful response Spit Dog…just me being jittery I guess..I received meds approx 3 weeks ago..it’s taken me this long to bite the bullet and commence treatment :)

    Tx naive. GT3a
    Female
    Diagnosed 1996

    Start 25/2/16
    VL 62700
    F0
    hb 141
    ALT 36
    ALP 81

    4 week test
    VL UND
    ALT 18
    ALP 70

    Additional 4 weeks Tx
    Start 19.5.16

    27 February 2016 at 8:41 am #12796
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Hi and welcome,

    Also not a Dr but with the one cup you will be fine, liquorice has been identified as a cyp3a4 inhibitor but I couldn’t find anything on how strong the effect was. As splitdog says and given you are only two days into treatment that won’t be a problem, just don’t keep drinking it. If you search the site for “CYP3a4” you should find plenty on what items to avoid.

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    27 February 2016 at 8:46 am #12797
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    Jack, I’m on the same (Sof/Dac) and am on week 6. I have virtually no side effects. Are you experiencing any?

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    27 February 2016 at 8:57 am #12798
    Avatar photoHit The Road Jack
    • Topics: 4
    • Replies: 24
    • Total: 28
    • Treatment Warrior
    • ★★★
    @hit-the-road-jack

    Just getting a response from you guys makes me feel less anxious..thanks for responding to me

    Tx naive. GT3a
    Female
    Diagnosed 1996

    Start 25/2/16
    VL 62700
    F0
    hb 141
    ALT 36
    ALP 81

    4 week test
    VL UND
    ALT 18
    ALP 70

    Additional 4 weeks Tx
    Start 19.5.16

    27 February 2016 at 9:00 am #12799
    Avatar photoHit The Road Jack
    • Topics: 4
    • Replies: 24
    • Total: 28
    • Treatment Warrior
    • ★★★
    @hit-the-road-jack

    Hi Spitdog

    Only 2 days in..no sides so far..(touch wood)

    Tx naive. GT3a
    Female
    Diagnosed 1996

    Start 25/2/16
    VL 62700
    F0
    hb 141
    ALT 36
    ALP 81

    4 week test
    VL UND
    ALT 18
    ALP 70

    Additional 4 weeks Tx
    Start 19.5.16

    27 February 2016 at 10:45 am #12805
    Avatar photo2b
    • Guardian Angel
    • ★★★★★
    @2b

    nah, can’t see one cup throwing off 12 weeks of killer meds, but like everyone else said,
    Stop doing that thing!

    GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””

    10 March 2016 at 6:48 pm #13630
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    This will have no impact.

    CYP3A4 inhibitors increase the levels of Dac so it is likely to:

    1. Be equally or more effective, but
    2. Give more side effects

    YMMV

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