On the issue of “genotype change”, it was postulated in another thread that someone could be co-infected with multiple genotypes but the test may only detect one. Possibly if G4 was detected and cleared, a co-infection with G3 could have been present and not cleared but detected in subsequent test. Only a theory but sounds more likely than genotype morphism.

And this is why I asked for a medical opinion and clearly we have one
Lets just relax
Relapsers from peg/inf like myself already suffer interferon induced anxiety (well a few do) we may have been on the phone alone in the night to lifeline while in that dark hole (I was)
I was like Lynne, alarms and red flags waving when I read this thread.
I agree lets just realise how early on we are as a tx cohort anyway, get on with staying positive of mind and all agree that there could be some data errors, some affiliates of big pharma, some speculation but that our common goal is to achieve a stress free future
It’s been a fascinating read since I first posted here and a hot topic
Cool down time? Phew!
Sending a splash of cool water
Ariel xxx

Hi Folks,

It seems like a lot of people are getting worried about that remark from Prof Gane about the *possibility* of relapsing with certain generics.

Dr James has verified by NMR that all the generics sourced by the FixHepC Buyers Club and that the generics manufactured by the companies recommended on the FixHepC web Forum are chemically equivalent to the patented molecules:

http://fixhepc.com/blog/item/16-testing-provisions-patient-safety.html

This means that apart from a few minor (and probably irrelevant) arguments about solubility and kinetics, Dr James has done everything humanly possible to show the generics that we all are taking may be assumed to be bio-equivalent to the patented molecules.

As several other people on this thread have already pointed out (mgalbrai, Price, Sirchinenge, GAJ, …, you just need to look at our forum signatures to see that the FixHepC generics are working extremely well. This is overwhelming evidence that there is no difference between the FixHepC generics and the patented molecules. The NMR spectra say we are taking the correct molecules. All the results posted so far say we are taking the correct molecules. So do not worry, do not fret! Molecules do not know about nationality or packaging. All the evidence so far says that the molecules made in China, India, and Bangladesh are the same molecules as the molecules made for Gilead in Ireland.

Here are some results posted previously by Dr James from previous trials using molecules made in the USA or Europe:

http://fixhepc.com/forum/questions-and-answers/644-query-8-week-protocol.html?start=6#9804

Probably a lawyer would say that NMR doesn’t prove bio-equivalence… The final proof will be the results from the REDEMPTION trials. I am sure that once the results are in they will show comparable or better statistics. Probably better because REDEMPTION will be the biggest trial ever.

Personally, I am already absolutely convinced that the generics I have been on are bio-equivalent. But I am a chemist, not a lawyer. REDEMPTION will provide the ultimate proof.

So for what its worth, my advice about the risk of relapse is this – DON’T WORRY, IT WILL PROBABLY NEVER HAPPEN.

But even if the worst does happen, it will be just bad luck and nothing to do with which little country (joke) you got your treatment from.

Yours,

Oor Wullie

(Expert in Catapults and Chemistry)

Hi ,
I am on TWINVIR and of course that I am worried.
I am worried about slow response, being UND in between week 8 and 9. Worried about viral load at EOT.
Worried about SVR at 4/12/24 weeks after EOT.
But I am not worried about the quality of sof/led of Incepta.
Because it was tested by specialists in Australia and because many people here and on other forums reached UND after 2/4/6/8/10 weeks.
I am not worried because I trust dr. James.
I am not worried because I will never afford the original licensed Harvoni 80000 USD or 40 000 Euro in France.
So I took my chance with generics, I bought Twinvir directly from Incepta. It was me and two other companions fighting for a life without HCV. In my country I am not sick enough to be treated with IFN free medication! I have to wait until F4, maybe F3.
Only time will prove if the desired SVR12 will be reached by each of us.
Only UND for all of us!

Man, everyone needs to take a collective deep breath

On occasion you need to have faith that this is all going to work out this is one of those moments.

Other wise you’re ruining what should be very happy time.

Yeah, seconded.

Please can someone change the title of this thread to “Prof Gane’s remarks: implications for total recovery”, move it to the “Don’t Worry” archive, and then close it from further posts?

Makes sense to me.

We have had it drilled into our heads that we wait…….

I will now happily wait for anything; the difference is my LFT’s are somewhat normal and any Hep C virus is hard to find.

What Prof Gane says is undoubtedly relevant and needs consideration.

Heard the concerns (always is about generics) before though, and made a decision that is applicable to me.

I am not posting this just to talk myself into believing everything will be okay. I just keep looking at the signatures and find that more relevant to me.

yours

J.

Yup exactly Mike
I threw a big cool bucket of water out yestey here didn’t it splash far enough
Yes we are the early cohort
Let’s be happy
I’m sure a lot of these remarks by Gane are trying to be constructive and can be interpreted a thousand ways but we are safe with our choices and in FANTASTIC care here with James and team
Here is some more soothing cool water