Understanding SVR - Why don't we call it cure?

This topic has 27 replies, 13 voices, and was last updated 8 years, 1 month ago by beaches.

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19 August 2016 at 2:14 am #22313
Matt-Kenney-google
- Topics: 1
- Replies: 423
- Total: 424
- Guardian Angel
@matt-kenney-google
You rock beaches
Nicely said. Thanks,

Matt

GT1a; Got it some time in the 70’s; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA NOT DETECTED”
19 August 2016 at 3:04 am #22314
Gaj
- Topics: 29
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- Total: 1,431
- Guardian Angel
@gaj
Matt-Kenney-google wrote:

You rock beaches

Oh, you’re gonna be in so much trouble Matt!

Hint: mermaids are known to hang around (with) beaches

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
19 August 2016 at 5:56 am #22325
Dr James
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- Total: 2,232
- Guardian Angel
@fixhepc
2. To provide peace of mind to Ariels head

This is a perfectly good reason to do the test.

One question that gets forgotten in medicine is this:

“What do you think it could be?”

I wasn’t taught to ask this in medical school, it was a bit of wisdom from a skilled clinician. The significance is that if I don’t ask that question, and treat that concern I might get the diagnosis 100% correct, and the treatment 100% correct, but have failed to address the real concern that brought the patient to my door.

YMMV
19 August 2016 at 6:22 am #22328
Sven
- Topics: 6
- Replies: 327
- Total: 333
- Guardian Angel
@sven
This week I have achieved more than in four years since the old tx and I am so grateful to FHC.

That is so awesome to hear because I and many others feel the same way.
Even my short UND, I can think clear, feel energy and know FHC is responsible.

Contracted HCV 1980’s
Geno Type 1a
F3 ( doc says once treated I’ll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count – 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 – Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
19 August 2016 at 6:35 am #22331
Matt-Kenney-google
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- Total: 424
- Guardian Angel
@matt-kenney-google
I feel a tidal wave size splash coming my way!!! Too late for me!!!!! SAVE YERSELVES!!!!

GT1a; Got it some time in the 70’s; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA NOT DETECTED”
19 August 2016 at 7:54 am #22338
Ariel
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- Guardian Angel
@ariel
I’m paddling as fast as possible here Matt so it’s a tsunami illy:' />
Y’know we mermaids and beaches can cause quite a stir haha!
Thankyou for your warm affirmative comments all
I’m done with pathology today and yes I feel lighter for it
Happy splashes from Ariel
19 August 2016 at 8:03 am #22339
Matt-Kenney-google
- Topics: 1
- Replies: 423
- Total: 424
- Guardian Angel
@matt-kenney-google
That’s “swell” (like a gentler tsunami) Ariel good thing for me you’re feeling lighter ..
Truly glad to hear it.
My best to you,

Matt

GT1a; Got it some time in the 70’s; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA NOT DETECTED”
20 August 2016 at 3:31 am #22368
Greedfighter
- Topics: 28
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- Total: 610
- Guardian Angel
@greedfighter
Well I’m SVR 16 and I feel like I am 20 again, I just don’t look it (55, and a few grey hairs) I feel so good, I will be shocked if I relapse. With these new Sofosbuvir combination treatments, it is a medical breakthrough comparable to the Polio vaccine. Dr. Freeman has said, SVR 12 is 99% and SVR 24 is 99.9%. So get checked at 12, 24 & 52 weeks. After one year, you are officially cured, I have never seen anything indicating a relapse after 52 weeks.
20 August 2016 at 5:13 am #22373
Sven
- Topics: 6
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- Total: 333
- Guardian Angel
@sven
GF … I hear you brother ! This medicine is like a miracle so far, I’ve never felt so good in three decades ! Awesome post & stay well.
In good health my friend.

Contracted HCV 1980’s
Geno Type 1a
F3 ( doc says once treated I’ll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count – 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 – Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!
21 August 2016 at 5:46 am #22396
nads
- Topics: 4
- Replies: 70
- Total: 74
- Recovery Champion
@nads
:”All hail the new kids”!!!! Its great to hear so many are feeling youthful again never mind a few grey hairs right? looking forward to the same! Thanks FHC for the chance!
Nadia xxxx

Diagnosed Hep C genotype 1b early 1990’s. Treated 1998 peg Interferon/Riba non responder ( Meds stopped after 4 or 5 months.
Fibroscan April 2013- 7.3kPa repeated May 2015- 5.8kPa mild scaring
May 2015 ALT 59 AST 56
21/7/2016 ALT 36 AST 44 BIL14
VL 939000
thanks FixhepC +Monkmed started Sof/Led 16/8/2016. )
OCT 3 AST33 VL UND
OCT 11 ALT 29 AST 36 VL UND
NOV 10 ALT 27 AST 37 VL UND
JAN 30 2017 ALT 23 AST 29 VL UND
SVR12 ALT 23 AST 27 VL UND!!
SVR 24 UND!!!TY EVERYONE!
1 October 2016 at 5:50 am #23401
A.L.
- Topics: 3
- Replies: 61
- Total: 64
- Recovery Champion
@a-l
”James-Freeman-facebook” wrote:

Hi A.L.

With the proviso that your ALT was elevated out of range pre treatment (a handful of patients with a significant VL have normal looking LFTs at baseline) then ALT elevation is a reliable marker for relapse. Elevations of LFTs for no obvious reason are the usual reason doctors look for HCV.

So, at SVR24, if your ALT is normal, and you’re not feeling any of the “usual suspect pre-treatment symptoms” then HCV RNA PCR is largely academic – we are not going to find anything. My reason for ordering it would be to remove patient doubt/anxiety, rather than because it’s strictly needed and I’m not already sure what the result is.

Thanks, Doctor.

That makes sense. I’m not overly concerned, especially as the stats for SVR12 are so well established, but out of curiosity, I might request some LFTs the next time I see my GP. This is a long-term process, so a little more information can’t hurt, especially if it is quick and not too draining on the public purse.

G4, F4, cirrhosis.

Thank you to Gilead, Michael Sofia, and the terrific folk at FixHepC for making this adventure possible.

YEAR….. ALT….. AST….. GGT… FERRITIN………………………………….
2009……. 210….. 215….. 953….. 1400……….. (Bad health, stupidity)
2015……. 60……. 45……. 150….. 360…………. (Improved diet and health, FixHepC treatment)
2016……. 20……. 24……. 25……. 156…………. (SVR 12)
1 October 2016 at 6:01 am #23404
fitz
- Topics: 9
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- Total: 499
- Guardian Angel
@fitz
If you’re in the US, there are private labs which offer this service.

LFTs are an inexpensive ‘out of pocket’ test.

Weighing one’s health against public largess is usually a no win equation.
1 October 2016 at 6:35 am #23408
beaches
- Topics: 10
- Replies: 750
- Total: 760
- Guardian Angel
@beaches
Gaj wrote:

Matt-Kenney-google wrote:

You rock beaches

Oh, you’re gonna be in so much trouble Matt!

Hint: mermaids are known to hang around (with) beaches[/quote]

lol much

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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