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TOPIC: Side effects for sofosbuvir/Daclatasvir combo.

Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #588

  • Nadia
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It must be your individual reaction then.
I hope iron suppliments do not interact with the drugs. I remember reading that they are not allowed with INF and riba.
Virus not detected from 14.10.2015
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #590

  • LondonGirl
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I remember people talking about 'smells' on the old treatments - Possibly the old triple with Boc or Telap or maybe Riba.
Smells and strange tastes. Maybe it's the bodys own reaction to the medicines attacking the virus, your own immune system?
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #591

  • wilko johnson
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i have read somwhere that smell perversions can be a side effect.but cant remember witch particular med it was.sof or dac.
gt3 started sof dac jan 2016 now 48 wks svr. not the real wilko johnson just have the same real name. shropshire uk
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #592

  • Ann Bee
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Hi Nadia,
I only started taking the iron 2 days ago, but yesterday and today no smell problems. When I first started the drugs 4 weeks ago I had only a few days of low grade flu symptoms, then was feeling the best I have in years, it is just the previous 4 days were terrible, but that has seemed to pass now. I only wrote this on this thread as I wanted to check if anyone else is experiencing these things or to help anyone who may be. Thanks for the reply Londongirl and wilko, that is interesting, I suspect it may be some variations on the liver re detoxing the drugs or somehow other being affected by them transiently.
I look forward to reading others experiences
Geno type 3a, infected approx 34-38 years ago. No fibrosis, treatment naive began chinese api daclatasvir/sofosbuvir 7/9/15.
17/12/15 finished treatment week 13 and virus Undetected
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #597

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I am having no issue with smell taste or appetite. I've had to eat very slowly though as i feel sick. I had four days of difficult flu like symptoms which abated for a day but now I am very worn out and sore. I am coughing more than I ever have but assume that's the meds telling me that my lungs are not what they should be. I am a smoker but have not been able to smoke for a week or so. Good news I suppose. This morning I felt terrible again after thinking yesterday I was getting over it. Interferon and RIBA did not affect me like this. I sailed through most of that. Quite strange how everyone is so different. Anyway I got up and at 'em this morning in an effort to feel better. It worked to some degree.

This stuff is no walk in the park. If I thought I might feel like this I would have prepared myself better. I have things planned for the coming month and seriously doubt if I can follow through. I hope things get better soon.
G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #598

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That is odd as I found the peg interferon and ribavarin a terrible experience
It's not something I want to revisit and so the new treatment side effects make me a little nervous
It almost broke up my marriage I was so difficult to be around - I'm pretty fit and hate being sick

Interesting though - I found my old blood tests as I'm preparing myself for new treatment through Dr freeman and the buyers club
In 2003 my AST was 263 and in 2012 it was 138 (normal is 10-40)
My ALT was 624 in 2003 and 240 in 2012 (normal is 5-40)
My blood count, lymphocytes and neutrophils were all outside of normal in 2003, but normal in 2013
The treatment didn't rid me of the virus, but forced me to focus on my overall health
Prior to 2003 my lifestyle consisted of quite a few things that would hurt my liver compared to 2013

My liver biopsy in 2003 showed significant damage
I am sure it is my improved lifestyle and use of herbs and products like lecithen every day contribute to the better results
but more importantly, would this mean that the side effects from any treatment would not be as debilitating?

I'm going for more bloods next week and so will have a comparison to 3 years ago
Will be interesting to see how it all looks

good luck everyone - to get rid of the virus would be an incredible feeling
I've had hep c for pretty much all of my adult life and I'm 52 in December
i don't know what feeling 'normal' is
I actually feel pretty good, but would i feel really good if i were to be rid of it
Are some of the funny things that i have due to the hep or just me?
I don't know
My previous treatment put me off doctors for 10 years
i feel a real sense of trepidation and excitement - nervicited as my niece says
52 y.o. G3a for about 30 years
Previous tx 2004 interferon/ ribavarin
2004: ALT 624 AST 263

Pre tx test 23/10/15: ALT 153 AST 128 VL 11 849 493
6/11/15: Sof/ dac started
26/11/15: ALT 41 AST 41
7/12/15: ALT 36 AST 30 Virus undetected

2004 biopsy F3
Fibroscan appt Jan 11 2016.
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #599

  • Vicki
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Hi everyone,
It's great to read your posts. Just for the record I'm treatment naive with Hep C3. I'm 9 days into the Sof/Dac treatment and yes those pills pong. I take mine during a meal in the morning and so far so good. There is a bit of a sour taste in my mouth occasionally. Also I'm feeling a little manic, but that might just be the excitement of a possible cure. I'm drinking lots of water and herb teas. I've stopped taking any vitamins and am eating really healthy foods. I don't fancy coffee which only happens if I'm sick or when I was pregnant. i will report if anything changes over the nest 10 3/4 weeks. All the Best
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #600

  • Ann Bee
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Hi Bloot. My bloods have been completely normal with only slight raises in ALT/AST over the 38 years I have had this virus. In the last 2 years they have been creeping up but not to the levels that you have ever had, but most importantly my overall health has been declining

I have been a healthy yoga type all of my adult life if you overlook the 1-2 years of destructive behaviour in my late teens when I contracted this virus. I really didnt take any alcohol during this time, or very little, but in the last few years I have drunken more regularly so that may be why there has been a change.

The only thing I really noticed over the years and so did those closest to me was that every few weeks etc I would get very bad fatigue for no apparent reason (deep bone like fatigue) that would last for 1 or 2 days, then go. More recently it has been my foggy brain getting so much worse and digestive problems which both immediately improved when I started the sof/dac 4 weeks ago. I really didnt know if that was what was causing those symptoms but both clearded within 1 week of starting, and I was feeling fabulous.

I am like you Bloot in that it has been part of my personality my whole adult life ( I am 58)so I dont know what I will be like when it is gone!
My son noticed that a sharp tone in my voice has disappeared completely since on the drugs!! What do you know!

I will look forward to hearing how you and everyone does on this regime
Geno type 3a, infected approx 34-38 years ago. No fibrosis, treatment naive began chinese api daclatasvir/sofosbuvir 7/9/15.
17/12/15 finished treatment week 13 and virus Undetected
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #601

  • Ann Bee
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Hi Vicki, great to hear how you are doing. Yes I had that bad taste as well, I take mine after dinner so I dont have to have nausea if it shows, so far so good. I also am not taking any thing else (except for some iron I take in the morning) and have found vegan type food the best for me (I am not normally a vegan) it just feels cleaner and no digestive symptoms.
Did you read the Daclat drug insert that James put up on the site? It states that if you take it close to a high fat/High carb meal (I think) you can reduce the absorption rate quite significantly. That is why I take it just before going to bed with a piece of vegetable or fruit etc to allay the bad taste.
Really look forward to your progress so keep us posted ok!
Geno type 3a, infected approx 34-38 years ago. No fibrosis, treatment naive began chinese api daclatasvir/sofosbuvir 7/9/15.
17/12/15 finished treatment week 13 and virus Undetected
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #621

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I'm still quite sore all over but my cough has somewhat disappeared. It seems most symptoms come and then go. It's still a bit of a battle but I know it will be worthwhile.
G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015
Last Edit: 4 years 1 month ago by Johnboy.
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #622

  • Vicki
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Thanks Ann. All the best for you too. Keeping well healthy and having a good support from friends and this website really is helps.
Last Edit: 4 years 1 month ago by Vicki. Reason: addition comment
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #675

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Ann Bee wrote:
Hi I am almost 4 weeks into the Daclat/Sofos regime as a Geno 3, and my side effects appear to be getting significantly worse.
The main one is severe fatigue and muscle weakness. I have also become very sensitive to smells and odours .
Overall I feel like I am a bit poisoned. I have not really taken much refined drugs most of my life, so I dont know if this is the issue.
When I get the capsules out to take the smell really alarms me as it smells like poison. I am having my week 4 bloods done at the end of this week so will see how it is all going, I am a bit worried as I must return to work tomorrow and am feeling very poorly.
Are there any other people on this regime that want to share their side effects?

Over the last few years I've been losing my sense of taste (food, that is, not clothes etc - I lost those a lot longer ago). I'd just put it down to getting older. But, just recently, it's started coming back. Weird! I'm about 5 weeks into Sof/Dac btw.
Last Edit: 4 years 1 month ago by Alsdad.
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #704

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Feeling better today. Even patches of quite good! Two weeks in.
G1 58yo F1 54,000 viral load Relapser 2003/4 Sof/Dac started 21/9/2015
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #736

  • Bloot
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Johnboy wrote:
Feeling better today. Even patches of quite good! Two weeks in.

Great news mate!
Just imagine all those nasty little virus thingies getting decimated to the point of extinction :woohoo:
52 y.o. G3a for about 30 years
Previous tx 2004 interferon/ ribavarin
2004: ALT 624 AST 263

Pre tx test 23/10/15: ALT 153 AST 128 VL 11 849 493
6/11/15: Sof/ dac started
26/11/15: ALT 41 AST 41
7/12/15: ALT 36 AST 30 Virus undetected

2004 biopsy F3
Fibroscan appt Jan 11 2016.
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Side effects for sofosbuvir/Daclatasvir combo. 4 years 1 month ago #808

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Just an update, over the last 2 days I have been feeling FANTASTIC!! The best energy in a long time (worked landscaping my large yard all yesterday, havnt been able to do that for a long time) . I changed taking my meds from last thing at night to breakfast time. Was waking very, very groggy prior to that. Again I have no idea if this is just coincidence in terms of timing etc, just putting it out there. I cant believe how good I feel. YES!! Good luck every body. I will be getting the end of my 4 weeks bloods done tomorrow and so will find out soon what they say.
Geno type 3a, infected approx 34-38 years ago. No fibrosis, treatment naive began chinese api daclatasvir/sofosbuvir 7/9/15.
17/12/15 finished treatment week 13 and virus Undetected
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