Fitz starts REDEMPTION 3 Trial

This topic has 306 replies, 32 voices, and was last updated 8 years, 4 months ago by fitz.

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19 June 2016 at 4:08 am #19469
CJ
- Topics: 10
- Replies: 362
- Total: 372
- Guardian Angel
@cj
Good luck to both of you, Fitz & Sven
Cindi x

J the young dragon slayer is:
HepC 1a since birth
Male aged 15
VL 2000000
Started Twinvir/ 10-11-15-then Sof/led.
NO sides so far !
after one week VL : 37
after 4 wks VL : UND !
EOT 2/2/16 UND.!
4 wks. post tx results….pending….
7/3/16 VL result : 4 week post tx: SVR !
12 weeks SVR !
24 wks SVR yeeaa!!
19 June 2016 at 7:55 am #19477
GT2
- Topics: 1
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@gt2
Hi Sven

Good to hear that your meds have been shipped. The first step is always the hardest …trusting strangers on the other side of the world to deliver life saving meds to your door. Time seems to slow down waiting for the meds to arrive. However after you’ve taken that first tablet, it’s amazing how time speeds up and how much better you feel.

I look forward to hearing how your treatment progresses over the coming weeks and months.

Best Wishes

GT2

1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Na√Øve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂
20 June 2016 at 9:19 pm #19579
fitz
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@fitz
June 20th, 2016

Went in for labs (bloods) today 3 days early. Specialist’s office called Sat. morning (which is very unusual) to let me know everything had been set up with the lab. I was rather surprised since I had spoken with a nurse last week, and she had said to go in nextThurs.

I asked about that, and no, the doctor wanted the lab results now. Originally, when I spoke with the nurse last week, they had just wanted routine metabolic panels. Apparently though, that had changed and a viral load has been ordered.

So far, aside from the previously mentioned emotional ups and downs – which have since subsided – mild (and I mean really mild) and fleeting headaches, dry patches of skin on my face, some minor insomnia – waking up around 3:00 AM, but eventually falling back to sleep, there isn’t really much to report in the way of side effects.

On the plus side, energy is generally pretty good and seems to be improving. Bruise like patches which had appeared on my left forearm prior to treatment are gone. Pulling on my jeans this morning I noticed they were looser than the last time I had worn them. Had to hitch my belt up to keep them from slipping down too far.

Waiting for the results which should be in by weeks end.
20 June 2016 at 11:00 pm #19581
fitz
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@fitz
June 20, 2016

Went in for blood draw at 7:00 AM. Got an email around noon. Metabolic panel results are in.

WaaaHooo!!! 12 days into tx, 12 DAYS, and ALT and AST levels are within normal ranges. ALT has dropped from 190 (most recent prior test Feb. 2016) to 32 – today. AST is down from 111 (most recent prior test Feb. 2016) to 19 – Today

ALT and AST have not been at these levels within memory. Both were slightly above normal prior to Interferon therapy, and skyrocketed while on Interferon. Levels dropped after Intf. but never to prior levels. I just assumed the damage had been done, and I was forever screwed….

What a triumph!!!!

Many thanks to Dr. James at GP2U and the fantastic team at Monkmed!
20 June 2016 at 11:15 pm #19582
beaches
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@beaches
Excellent news buddy

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
20 June 2016 at 11:25 pm #19583
Hazel
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@hazel
Brilliant results Fitz. It’s all very well seeing it work for everyone but to get that normal liver function after years ourselves is such a milestone. It’s happening!

Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
21 June 2016 at 12:16 am #19586
Ariel
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@ariel
Massive drops in labs! You rawk Fitz, on the way full clear now to UND this was awesome to wake up to
Good morning from Australia and Ty for the awesome news
It’s working its magic
Yay!
Happies to you full of salty splashes
Ariel
21 June 2016 at 1:54 am #19595
pat1
- Topics: 5
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@pat1
here’s to your good health Fitz
you must be feeling sooo stoked
amazing path results

gt 1a VL 6m
F2/3 FibroScan – 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
.forever grateful to fixhepc
21 June 2016 at 2:20 am #19597
Gaj
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- Guardian Angel
@gaj
Congratulations Fitz! Those are great LFT results.

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
21 June 2016 at 3:08 am #19603
Tina-Hill-facebook
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- Guardian Angel
@tina-hill-facebook
fitz wrote:

June 20th, 2016

Went in for labs (bloods) today 3 days early. Specialist’s office called Sat. morning (which is very unusual) to let me know everything had been set up with the lab. I was rather surprised since I had spoken with a nurse last week, and she had said to go in nextThurs.

I asked about that, and no, the doctor wanted the lab results now. Originally, when I spoke with the nurse last week, they had just wanted routine metabolic panels. Apparently though, that had changed and a viral load has been ordered.

So far, aside from the previously mentioned emotional ups and downs – which have since subsided – mild (and I mean really mild) and fleeting headaches, dry patches of skin on my face, some minor insomnia – waking up around 3:00 AM, but eventually falling back to sleep, there isn’t really much to report in the way of side effects.

on the plus side, energy is generally pretty good and seems to be improving. Bruise like patches which had appeared on my left forearm prior to treatment are gone. Pulling on my jeans this morning I noticed they were looser than the last time I had worn them. Had to hitch my belt up to keep them from slipping down too far.

Waiting for the results which should be in by weeks end.

Hi Fitz
Firstly those LFT’s are stellar! you must be feeling like a teenager again
My train of thought in relation to your doctor wanting your results earlier – my gut instinct thinks this is a good sign as they are excited about the generic’s and their effectiveness and maybe this doctor will be willing to prescribe for others?If this is the case then woohoo!! as it’s no small feat to change the opinion of a skeptic.

SVR 24
21 June 2016 at 5:12 am #19615
mgalbrai
- Topics: 28
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- Guardian Angel
@mgalbrai
Your liver is thanking you!
Amazing!
m

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
21 June 2016 at 5:43 am #19621
GT2
- Topics: 1
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- Guardian Angel
@gt2
You’re really kicking HCV to the gutter Fitz.

Less than 2 weeks into treatment and:
ALT dropping from 190 to 32
AST dropping from 111 to 19

… forever screwed … don’t think so … only by your health insurance that knocked back your DAA treatment request after waiting over a year … now, that’s being screwed over …

Cheers

GT2

1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Na√Øve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂
22 June 2016 at 6:08 am #19696
Debs
- Topics: 6
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- Guardian Angel
@debs
Well done fitz, it’s looking good!
22 June 2016 at 6:32 am #19699
fitz
- Topics: 9
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- Total: 499
- Guardian Angel
@fitz
Thanks guys. I’m pretty stoked , especially after seeing Meg’s UND. result at two weeks!

Apparently a viral load assay was not ordered. After messaging my specialist, I got a call from a slightly flustered nurse today. They want me to come in to the office. I’ll find out more about that tomorrow.

They have a Phlebotomist (a fancy word for someone who draws blood samples) at the specialist’s office. I guess they want to make double sure I didn’t send someone else in (a ringer!) for yesterday’s Labs?

My guess is I’ll have blood drawn again. Will update.

Fitz
22 June 2016 at 6:52 am #19700
Meg
- Topics: 3
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@meg
Hey I missed your last post yesterday.
“smashing ” results indeed !! wow what a drop!
so happy for you Fitz

Blood transfusion in 1992 – Diagnosed in 2007
Tx naive -G1b – F1
VL 2.270.000
ALT 40
Start tx June 4th/2016 with DAAs – Sof/Led from India
Bloods on two weeks of tx (June 18th)
AST 17 – ALT 10 – GGT 19
Virus UND
Bloods on six weeks of tx (July 16th)
AST 17 – ALT 8 – GGT 12
Virus UND
EOT on August 8th (did 9 weeks and 3 days)

SVR 4 Virus UND (September 7th)
AST 13 – ALT 5

SVR 14 Virus UND (November 12th)
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