HCV RNA UNDETECTED

This topic has 50 replies, 18 voices, and was last updated 8 years, 7 months ago by Ariel.

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12 January 2016 at 12:39 pm #8773
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Good morning reading Tina & Hamilton

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
12 January 2016 at 1:09 pm #8776
Hamilton-Gray-facebook
- Topics: 6
- Replies: 29
- Total: 35
- Treatment Warrior
@hamilton-gray-facebook
Thank Tina & London Girl.

Male aged 66, contracted hepC 45 years ago
Failed treatment interferon and Ribavarin 2003
Started treatment 22 October 2015, 24 week, Dr Freeman
Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin
Geno 1a
Fibrosis F3/4
VL <12 at 4 weeks
VL – negative at 12 weeks
12 January 2016 at 2:24 pm #8783
Enkel
- Topics: 16
- Replies: 293
- Total: 309
- Guardian Angel
@enkel
Hi Tina,

<12 means detected and < LLOQ. Thats a very good results. Even < 12 at the EOT or 12 weeks still have a 97% cure rate.

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
12 January 2016 at 7:06 pm #8793
Tina-Hill-facebook
- Topics: 28
- Replies: 705
- Total: 733
- Guardian Angel
@tina-hill-facebook
mmmm turns out the woohoo banana doesn’t want to dance for me… oh well in that case

WOO HOO!!!!!

Thanks Enkel

SVR 24
18 March 2016 at 1:53 pm #14111
darbara
- Topics: 6
- Replies: 166
- Total: 172
- Guardian Angel
@darbara
Just to add to this thread at 4 weeks into treatment my V/L was <25 and it clearly mentioned on the report as VIRAL LOAD IS BELOW LLOQ NO HCV-RNA detected. I am on Harvoni from Gilead. I consider this as undetected so does the doctor.
So I guess it depends on the test. Now waiting for the EOT V/L results.
Personally I would consider <12 as undetected maybe the lab guy forgot to mention UND.
But as we all know SVR 12 AND 24 is all that matters so be it <12 or <25 its a great result which shows the medicine has CLEARLY worked or working.

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
18 March 2016 at 2:23 pm #14114
darbara
- Topics: 6
- Replies: 166
- Total: 172
- Guardian Angel
@darbara
http://hepatitiscnewdrugresearch.com/hcv-viral-load-test.html

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
18 March 2016 at 7:08 pm #14126
isaing4
- Topics: 2
- Replies: 237
- Total: 239
- Guardian Angel
@isaing4
Thank you darbara for the link with hcv viral load test!

Congratulations for your EOT with UND!

HCV since I don’t know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful 🙂
virus not detected 06.02.2016 & SVR24
isaing4@gmail.com
12 April 2016 at 10:27 am #15298
flyingfox66
- Topics: 2
- Replies: 170
- Total: 172
- Guardian Angel
@flyingfox66
So is <15 in a quantitative test Undetected or not??
Doesn't say detected or undetected. I guess at least there's no point doing any more quantitative tests.

F49HepC25ysGT1a
mild”
12 April 2016 at 10:57 am #15299
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Hi FFox,

My last VL test said ‘<12 Detected but unable to quantify'

So, there is some virus detected but it's too low for the test to count. Now, it could be 11 copies or it could be 4 - Hence the confusion. Some people say the test can pick up 'dead virus' ie virus that cannot multiply or make a chain any more and somewhere I read the virus needs 10 copies to multiply. So it could be seen as UND but there's a chance it may not be gone completely (eg 11 copies ) unless it states Undetected'. Well, mine stated detected, so there is no certainty. I have read of a few people having <12 unq for a few tests in a row, then post EOT they are clear, as I say, it's a bit vague! I am still looking for the word UND so as to be sure.

Hope this makes sense!

lg xx

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
12 April 2016 at 11:46 am #15306
flyingfox66
- Topics: 2
- Replies: 170
- Total: 172
- Guardian Angel
@flyingfox66
Thanks LG
It’s a bit frustrating that they don’t say either undetected or detected on the results!
But either way I guess its pretty good for 32 days.
When my GP rang he said “it’s gone!” and I got all excited…but then when I got the hard copy I was back down the roller coaster.
I should have remembered he was one of the clueless.
Maybe you need to do a qualitative next, and that will give you an UND. That is what I am going to ask for when I see my specialist at the end of the month.

F49HepC25ysGT1a
mild”
12 April 2016 at 12:06 pm #15307
isaing4
- Topics: 2
- Replies: 237
- Total: 239
- Guardian Angel
@isaing4
flyingfox66 wrote:

So is <15 in a quantitative test Undetected or not??
Doesn't say detected or undetected. I guess at least there's no point doing any more quantitative tests.

Hi flyingfox,
Check this out, Dr. James explanations!
Hope it helps!

http://fixhepc.com/forum/viral-load-results/478-viral-load-test.html#6365

HCV since I don’t know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful 🙂
virus not detected 06.02.2016 & SVR24
isaing4@gmail.com
12 April 2016 at 12:17 pm #15309
flyingfox66
- Topics: 2
- Replies: 170
- Total: 172
- Guardian Angel
@flyingfox66
Thanks Isaing
Thats the thread that sent me back down the roller coaster. At least it has a happy ending!

F49HepC25ysGT1a
mild”
12 April 2016 at 12:34 pm #15312
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Frustrating indeed FF ! Can you call the lab?

My GP has just requested VL Test, so if it comes back again <12 I'll ask him for qualitative, if he refuses, I guess I'll pay. I have 10 more weeks of treatment, so ...

Hope you get it sorted ! xx

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
12 April 2016 at 1:05 pm #15315
flyingfox66
- Topics: 2
- Replies: 170
- Total: 172
- Guardian Angel
@flyingfox66
Yeah I might try and ring them LG.
They will probably be a bit shocked at being pestered by a patient but its worth a try.
I liked this comment I got from Archie on FB…
“If you take a quantitative out of one arm and a qualitative out of the other one will come back <15 and the other will be UND. People put to much emphasis on one word. <15 is a great result!"
Cheered me up!
xox

F49HepC25ysGT1a
mild”
12 April 2016 at 1:27 pm #15316
Gaj
- Topics: 29
- Replies: 1,402
- Total: 1,431
- Guardian Angel
@gaj
FF, your GP has told you that “it’s gone!” but the certificate you have been given doesn’t clearly state that. Your GP needs to clarify what he told you and why the certificate doesn’t state that. If that means he needs to contact the lab then that is what he should do.

But as you say, either way it is a good result and within expectations after 4 weeks.

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
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