Darbara.
I am f3/f4.I am into wk 11 of Sof Dac Riba.I have elected to add another 12wks of sof dac(if it arrives in time from the Buyers Club) and another 6 wks of Riba,(which is when my Riba supply runs out,I don’t want to have to buy any more,and I fall a couple of wks short of it being on the PBS).
So that will make a total of 24wks of sof dac and 18wks of riba.
According to the EASL guidelines this is overkill.According to the AASLD guidelines its what is required.From the experts I get a mishmash of opinions.I want to be in the 95% plus success cohort.The Riba hasn’t been kind at times,but it hasn’t clipped my wings at all.My partner often asks when is she going to get the real Miko back.
What has been my biggest encouragement is a guy up the street that is 10yrs younger than me and who has Parkinsons Disease.I often see him painfully shuffling down to the shop.I look at his agony and think “what the hell have I got to winge about,at least I have a good chance of a cure,He has none.”
It is amazing how quickly time passes.It’s so little to put up with for so much to gain.
Go for the max Darbara and cut down your risk of failure to the minimum,and don’t even contemplate failure..

if fail 24 weeks of harvoni, will there be any options left

RELAPSE after four treatments!
HCV, G1b, F4, Child A-B!
Bad news! Mom has four treatments, the latter is Harvoni and she has relapsed!
First Treatment – 2000 Interferon / Ribavirin
Second Treatment – 2009 Peg Interferon / Ribavirin
Third treatment – 2015 Sovaldi / Ribavirin 24week
Fourth treatment – 2016 Harvoni 24week
Relapse!
Please give me advice what medicine to continue?

Hi Marilen,

Sorry to hear that your Mother relapsed again. As splitdog says Sofosbuvir/Velpatasvir (Epclusa) + GS-9857 is an option that looks excellent for the future although there may be others available now that would suit genotype 1b.

However, as four treatments have already failed her and noting her cirrhosis status, I would recommend that she seeks further expert advice by making an appointment for an international (Skype) consultation via GP2U Telehealth https://gp2u.com.au where her history and medical records can be reviewed in detail and recommendations made. Dr James Freeman usually has appointments available on Friday’s but other doctors there could assist if those days don’t suit. If you have further questions for GP2U their “contact us” details are here https://gp2u.com.au/contactus

Have u started retreatment GAJ?

RELAPSE after four treatments!
HCV, G1b, F4, Child A-B!
Bad news! Mom has four treatments, the latter is Harvoni and she has relapsed!
First Treatment – 2000 Interferon / Ribavirin
Second Treatment – 2009 Peg Interferon / Ribavirin
Third treatment – 2015 Sovaldi / Ribavirin 24week
Fourth treatment – 2016 Harvoni 24week
Relapse!
Please give me advice what medicine to continue?

Hello Marilen,

Without knowing more details this advice should be viewed as generic.

There are several options to consider.

1) Wait for better drugs – this is unlikely to help as your mum is near the end
2) Do inexpensive maintenance therapy with say Sofosbuvir + Daclatasvir like we would do with HIV while we wait for better drugs. This might well be the best option
3) Do Sof+Dac or Sof+Led or Sof+Vel PLUS Ribavirin for 24 weeks
4) Look to do a curative 3 or 4 (or even 5) drug regimen. Options are things like Sof+Dac+Simeprevir or Asunaprevir, Viekira-pak + Sofosbuvir, Zepatier + Sofosbuvir and all with ? + Ribavirin

With Child’s Pugh A/B Viekira has a black box warning so it’s not a good option, but like I say, this is not a discussion that can be done via online posts and your budget needs to be considered. It looks like you are getting insurance coverage so funded Zepatier + Generic Sofosbuvir might be an option. The trial the underpins that is called C-SWIFT.

http://www.aidsmap.com/Treatment-intensification-with-sofosbuvir-permits-cure-after-failure-of-previous-HCV-treatment/page/3014995/