Ledifos now available

This topic has 52 replies, 12 voices, and was last updated 9 years, 4 months ago by klhilde.

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29 November 2015 at 11:07 am #4811
darbara
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- Guardian Angel
@darbara
http://timesofindia.indiatimes.com/home/science/Hepatitis-C-cure-may-cost-as-low-as-Rs-67k/articleshow/49966218.cms

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
29 November 2015 at 12:14 pm #4813
emilio
- Topics: 13
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- Guardian Angel
@emilio
Hi Dabara

I wasn’t questioning the validity of the planned generic drugs that are about to come out of India, it was more to do with random pictures which none of us can verify 100% without additional evidence. Em
8 December 2015 at 9:51 pm #5560
darbara
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- Guardian Angel
@darbara
HYDERABAD, DEC 8:
Generic pharmaceuticals and anti retroviral drug manufacturer Hetero has received approval for the fixed dose combination drug Ledipasvir sofosbuvir from the Drug Controller General of India (DCGI).

The drug, Ledisof, is a generic version of Gilead Sciences’ brand Harvoni which is approved by the US FDA.

The Hyderabad based Hetero had singed a non-exclusive licensing agreement with Gilead in September last year to manufacture and market the drug indicated for the treatment of chronic hepatitis C and is the first company to receive DCGI approval for this category of drug.

“We are happy to extend the fixed dose combination therapy Ledipasvir sofosbuvir (Ledisof) to Indian patients which is much more effective than Sofosbuvir,’’ B P S Reddy, Chairman and Managing Director of Hetero said in a release issued here on Monday.

Hepatitis C is a growing health concern in many developing countries including India which is estimated to have about 12 to 18 million people infected with hepatitis C.

(This article was published on December 8, 2015)

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
8 December 2015 at 10:12 pm #5561
Enkel
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- Guardian Angel
@enkel
Hetero is a reputable company. Hetero has revenues over $1 billion and reported a profit of $100 million in last fiscal year. I really dont understand these doctors who dont believe in these big companies.

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
8 December 2015 at 10:44 pm #5565
dointime
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@dointime
Enkel,

I am not sure it is because the doctors don’t rate the companies involved. After all, the UK NHS uses generics from these companies for about 40% of their scripts I believe. They wouldn’t do that if they thought the companies were rubbish.

So go figure.

dt
8 December 2015 at 10:50 pm #5567
Enkel
- Topics: 16
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- Guardian Angel
@enkel
Considering that Gilead takes the APIs from Jordan, I would say that Ledifos is original and Harvoni is generic

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
8 December 2015 at 11:35 pm #5575
Virtuose
- Topics: 0
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- Total: 7
- Novice
@virtuose
Wasn’t it supposed to be Ledifos and not Ledisof…?

http://www.business-standard.com/article/pti-stories/hetero-gets-dcgi-approval-to-market-hepatitis-c-drug-115120800640_1.html

It says on Ledifos bottle that it is only for sale in India, so the same as Ledisof (for Indian patients only) – so really don’t understand why hetero now needs two different brand names for the same product to be manufactured for Indian patients only…?
Lisof is for Nepali market only…
12 December 2015 at 7:23 pm #6087
Enkel
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- Guardian Angel
@enkel
One more time is Ledifos, not Ledisof

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
12 December 2015 at 8:52 pm #6089
Virtuose
- Topics: 0
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- Total: 7
- Novice
@virtuose
One company cannot market the same drug under two different brand names on the same market (Indian). So it has to be a typo in the official announcement made by hetero….?

http://heteroworld.com/view_news.php?id=460
12 December 2015 at 8:56 pm #6090
Enkel
- Topics: 16
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- Total: 309
- Guardian Angel
@enkel
typo the persons who write on web are not pharmacist

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
12 December 2015 at 9:09 pm #6091
Virtuose
- Topics: 0
- Replies: 7
- Total: 7
- Novice
@virtuose
I really doubt that it is a typo as it’s been already 4 days since the announcement was out. They would’ve already changed it to Ledifos. But let’s see…
Ledisof mentioned 3 times in the announcement – so 3 times typo) 2nd biggest pharm company in India
12 December 2015 at 9:16 pm #6092
Enkel
- Topics: 16
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- Total: 309
- Guardian Angel
@enkel
the bottle above has the production date dec 2015. So it is typo 100%

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
13 December 2015 at 11:18 am #6135
DorianLS
- Topics: 2
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- Total: 21
- Treatment Warrior
@dorianls
I have found misspellings and incorrect grammar are common in India.
It is certainly a typo.
13 December 2015 at 11:33 am #6136
DorianLS
- Topics: 2
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- Total: 21
- Treatment Warrior
@dorianls
I just received a reply from a pharmacy in India that they can now ship to me Ledifos. The price is $395 USD. The company does business as Medsure (http://www.medsure.in/about-us.html) as well as New Global Enterprises. The fellow in charge is: Vivek Ramteke (91-909684376. I don’t understand how he can ship now as I have not heard yet that the generics can be sold in India. Has anyone heard of Vivek Ramteka?
13 December 2015 at 12:09 pm #6137
klhilde
- Topics: 30
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- Guardian Angel
@klhilde
I’m assuming that’s US$395 for a bottle of 28 tablets?

US$1185 for a 12 week treatment is a good price. Makes me wonder how low they can go with the Sof/Dac combo.

The press release about Hetero’s approval was Dec 8. I don’t know if any distributors have the drugs in stock yet. They may have had them for quite a while or they may only have accepted orders outstanding with Hetero waiting to be filled. Either way, as it’s a new drug on the market you should expect hiccups in order fulfillment for a while.

In any case, it likely won’t stop an India distributor from taking your order today if he’s confident that he’ll have the meds in a week or ten days … and it won’t stop a scam company from taking your order either.

The point being, be certain who you’re dealing with. So far we haven’t seen a single case of a legitimate manufacturer whose Hep C drug didn’t meet standard … supply chain integrity is far more likely to be a problem for people ordering internationally … just be careful.

If you do successfully order, please let us know how it turns out as soon as possible. Verified sources are good to know. And then we’ll also want to see your treatment results, so don’t forget to report back regularly.

Thanks
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