Home › Forums › Main Forum › FixHepC Admin › Q & A › Missed dose – worried – should I take extra?

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  • 20 January 2016 at 7:23 am #9883
    Avatar photoPhoenix
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    • Recovery Champion
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    @phoenix

    Hi, was 2 and a half hours late with my dose today. How bad is that? How much more depleted would the medication have gotten in my body in that time? Should I take an extra dose today to try and nuke any viruses that were encouraged to develop resistance by the holiday I gave them? :huh:

    20 January 2016 at 7:24 am #9884
    Avatar photoPhoenix
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    @phoenix

    I should add that I’m on day 20 of sof & dac.

    20 January 2016 at 7:33 am #9886
    Avatar photoJoy
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    @joy

    Can’t find the post now but recall Dr James saying don’t be alarmed if you’re a bit off schedule. I wouldn’t take an extra dose without speaking to the doc first.

    I took mine just before bed, which ranged from 10pm – midnite.

    20 January 2016 at 7:34 am #9887
    Avatar photosplitdog
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    @splitdog

    2 1/2 hours I would think is nothing. No worries……

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    20 January 2016 at 7:58 am #9891
    Avatar photoCC2B
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    @cc2b

    You should be fine 2.5hrs isn’t too bad. I do remember reading something about it on here. Someone will find it or maybe Dr Freeman will get back to you. Do not take extra dose! I do remember that part of it.

    GT2b diagnosed 10/2015
    since: unknown
    11/20/15 VL= 214,070
    12/4/15 ALT=18 AST= 24
    1/16/16 started sof/dac
    2/13/16 @4wks VL=UND ALT=13 AST=22
    3/12/16 @8wks VL=UND ALT=10 AST=18
    4/9/16 EOT VL=UND ALT=11 AST=19
    9/23/16 SVR24 ALT=11 AST=22

    20 January 2016 at 8:01 am #9892
    Avatar photoJoy
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    @joy

    Found it!

    http://fixhepc.com/forum/patient-stories/326-time-of-day-to-take-medication.html#3025

    20 January 2016 at 9:20 am #9894
    Avatar photoPhoenix
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    @phoenix

    Thanks very much for that Joy – it’s immensely reassuring! :)

    20 January 2016 at 12:34 pm #9901
    Avatar photoPaul-Jarman-facebook
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    @paul-jarman-facebook

    Sometimes my doses have been off by 6 hrs due to shift work then I just take them when I can.

    Just to clarify for most of the time it’s regular 24 hr periods but I seem to be about 3 few days in front :)

    Two time relapser.

    SVR 4 achieved 12/16 at last
    SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

    GT 3 – about 28 yrs with HCV

    20 January 2016 at 12:59 pm #9904
    Avatar photoCJ
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    @cj

    My J had to miss one whole day one time when he had a gastro bug :ohmy:
    But that was OK, Dr James said.

    So don’t worry :)
    x

    J the young dragon slayer is:
    HepC 1a since birth
    Male aged 15
    VL 2000000
    Started Twinvir/ 10-11-15-then Sof/led.
    NO sides so far !
    after one week VL : 37
    after 4 wks VL : UND !
    EOT 2/2/16 UND.!
    4 wks. post tx results….pending….
    7/3/16 VL result : 4 week post tx: SVR !
    12 weeks SVR !
    24 wks SVR yeeaa!!

    25 January 2016 at 1:23 pm #10374
    dope-on-a-rope.jpgDr James
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    @fixhepc

    Hello Phoenix,

    It is not even a slight worry. Only very low dose things like the mini pill require taking within a 3 hour daily window to be effective.

    In the PROTON study people taking 200 mg of Sofosbuvir+Riba had a 90% SVR rate, versus a 91% rate for 400 mg. You are not taking mini-sofosbuvir.

    YMMV

    23 February 2016 at 6:13 am #12484
    Avatar photoPhoenix
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    @phoenix

    Thanks all. Very reassured! :)

    Sorry no reply for a while – been trying to just take the pills, then avoid all thoughts of disease and just live…

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