NATCO Pharma ... Sof, Dac, Sof/Led Combo

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13 December 2015 at 3:03 am #6121
klhilde
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- Guardian Angel
@klhilde
NATCO Pharma

Home

Checking on reliable international pipeline

Contact Info on site

Available Products:

Hepcinat (Sofosbuvir 400mg)

Natdac (Daclatasvir 60mg)

Hepcinat LP (Sofosbuvir 400mg / Ledipasvir 90mg)
13 December 2015 at 1:45 pm #6146
LondonGirl
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@londongirl
Are they offering an actual ‘shipping from’ date?

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
13 December 2015 at 3:24 pm #6159
klhilde
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@klhilde
Not yet … that I know of … just getting the thread ready. The bigger issue is finding the trustworthy distributors. Haven’t got that yet either. I’m going to have to do some digging.
15 December 2015 at 1:24 pm #6342
darbara
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@darbara
Natco Pharma Limited (NSE: NATCOPHARM; BSE: 524816) announced today that it is the 1st company in India to get approval for generic Daclatasvir Dihydrochloride (“Daclatasvir”) tablets, 30mg & 60mg, from Drugs Controller General (India). Daclatasvir is the first-in-class NS5A inhibitor used in combination with Sofosbuvir for the treatment of patients with chronic hepatitis C virus (HCV) genotype 3 infection. Compared to other treatment options, this combination not only increases the cure rate, but is also regarded as a valuable treatment option in some of the difficult-to-treat HCV patient subsets.

Natco will market generic Daclatasvir under its own brand NATDAC, and through its strategic partners in India. Natco will launch Immediately in India at an MRP of Rs.6000/-(Rupees Six thousand only) and Rs.4000/- (Rupees Four Thousand only) for the 60mg and 30mg strengths, respectively, for a bottle of 28 tablets.

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
15 December 2015 at 2:16 pm #6350
klhilde
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@klhilde
6000 rupees … about US$90 for a 28 tab bottle of 60mg Dac … $270 for 12 weeks at suggested retail… so could go even lower.

I wonder why they aren’t willing to say “pan-genotypic”? Scared they’ll not sell off their Led?
15 December 2015 at 2:29 pm #6351
Alsdad
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@alsdad
Wonder if Doc James could enlighten us on the reasoning behind producing 30mg Dac tablets when he’s got a minute?
15 December 2015 at 3:40 pm #6358
klhilde
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@klhilde
Wow … it doesn’t take google long does it.

I just did an image search for Natco Natdac …. and a ways down the screen there I am … my picture to your left.
15 December 2015 at 3:50 pm #6359
Paul-Jarman-facebook
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@paul-jarman-facebook
Just found it Kev lol not long at all, your famous

Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated

GT 3 – about 28 yrs with HCV
15 December 2015 at 4:07 pm #6360
klhilde
- Topics: 30
- Replies: 223
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- Guardian Angel
@klhilde
Ya probably just a strange chance timing of my post right before google’s machine rolled through here.

But if Natco doesn’t get some product pics up quick your guitar will be beside me on that page by tomorrow.
16 December 2015 at 4:08 pm #6448
Enkel
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@enkel
I guess people under 60 kg needs 30mg dac

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
16 December 2015 at 4:37 pm #6449
LondonGirl
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@londongirl
This is interesting! would the same possibly apply to Sofo/Led I wonder? tricky uf in the form of a combined tab

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
17 December 2015 at 2:13 am #6486
Gaj
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- Guardian Angel
@gaj
Without wanting to second guess the Doc on this. Because of the large group of inhibitor and inducer chemicals that effect Dac, the 30mg allows doses of 30 or 90mg if you also have to take a medication that effects the efficiency of Dac. I’m pretty sure that otherwise the dose remains 60mg for a wide weight range although someone less than half the standard weight may be considered for a 30mg tab. Eg if you only weighed 30kg or so.

G

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
17 December 2015 at 2:33 am #6487
zhuk
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@zhuk
The issue of bodyweight > Dac dosage has been discussed a bit…far as I’m aware 60mg is still the recommended dosage across all general weight-ranges (I fall on about the 50kg line, and although I’m expecting increased sides don’t plan on dosage adjustment)

You might have a point on those of very low weight, Enkel…though 30kg/around 4 1/2 stone would be likely talking pediatric doses at that weight range.

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
17 December 2015 at 3:07 am #6489
Gaj
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@gaj
Thanks zhuk,

Yes, I was also thinking along the lines of pediatrics or similar. Should have highlited the “may” and ” considered” in my post and added “on medical advice”.

G

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
17 December 2015 at 3:28 am #6491
zhuk
- Topics: 5
- Replies: 543
- Total: 548
- Guardian Angel
@zhuk
No probs GAJ

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
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