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  • 31 December 2015 at 4:28 am #7599
    Avatar photosonix
    • Guardian Angel
    • ★★★★★
    @sonix

    Two weeks into Tx, I’ve been meaning to post but finally.

    Pre-Tx symptoms –
    – fatigue and mind fuzz
    – muscle and joint pain (I have osteoarthritis and fibromyalgia, not severe though)
    – prickly skin, also dry and itchy in places
    – temperature sensitivity. Sweats and/or shivers regardless of temperature
    – seborrheic dermatitis
    – depression/anxiety

    Pre-tx pathology –
    – Gt 1a
    – VL 230,000 IU/mL Log10 5.35
    – Fibroscan 7.8kPa F1/2
    – Haematology all normal except for platelets 145 (150-450) was 48 6 months ago when I had dengue fever
    – Chemistry normal except AST 45 (<41) ALT 64 (<51)
    - Endocrinology normal AFP 7 (<9)

    Treatment naive, probably had HCV since late 1980s from using naughty drugs.
    Started Sof/Dac from Kingswood Compounding Pharmacy on 17/12/2015. Script from Dr James via GP2U.

    After 2 weeks Tx I'm feeling vastly more energetic but wired from lack of sleep, about 5 hours per night. I changed from evening dose to after breakfast to try to alleviate this, stay tuned. I definitely have that speedy feeling others have mentioned. No other noticeable side effects. It's been stinky hot in Melbourne for a lot of days since I started so this may have masked some milder sides.
    For years I have suffered depression and anxiety but this seems to be abating somewhat now the stigma of having HepC is weighing less on my mind. I took paroxetine for years but went cold turkey (after ramping down) when visiting Vietnam for 3 months in 2008. After a few weeks of mind spins it settled down and started to handle life ok without it. I now believe SSRI was useless or even harmful in my case.

    Looking forward to 4 week blood results and feeling very positive about this.
    Onward and upward! :woohoo: B)

    M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
    SVR4 at 7Apr16 ALT 22 AST 22
    SVR12 at 9Jun16 ALT 23 AST 25
    Melbourne, Australia

    31 December 2015 at 4:41 am #7600
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    Are you in Australia?

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    31 December 2015 at 4:43 am #7601
    Avatar photosonix
    • Guardian Angel
    • ★★★★★
    @sonix

    Yes, Melbourne.

    M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
    SVR4 at 7Apr16 ALT 22 AST 22
    SVR12 at 9Jun16 ALT 23 AST 25
    Melbourne, Australia

    31 December 2015 at 4:45 am #7602
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    I’m in the US. I just ordered Sof/Dac from Kingswood as well. Waiting for the postman………:)

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    31 December 2015 at 5:17 am #7603
    Avatar photopoodle
    • Guardian Angel
    • ★★★★★
    @poodle

    Hi Sonix Thanks for posting all the info. Iam also 1a 30 plus years. Can I ask why you decided on sof/dac and not sof/led ? Cheers, and Happy new year. Jill

    Geno1a 35years fibrosis 2 or 3 different results from different hospitals ??
    24weeks mesochem sof/led as unsure of fibrosis status.
    currently UND. No bad side effects
    Have svr12 … waiting for svr 24
    I now have SVR 36 weeks.

    31 December 2015 at 5:25 am #7604
    Rich-Kohler-facebook
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    • Novice
    • ★
    @rich-kohler-facebook

    Did you need a script for that?

    31 December 2015 at 5:43 am #7605
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Sonic I live in Bendigo and can relate to the hot weather Phewww

    I am in week seven on Sof/Led and also have the insomnia and still do but sleeping a bit longer than when I first started. I take my meds at around 8.30pm and find now that I am not tired in the mornings when I get up (work full time) and energy levels improving also. I turned 60 this year and have no idea when, where or how long I have had the virus but I am forever grateful for Dr Freeman and the Buyers Club for the opportunity to be able to take my meds now rather than waiting for an appt at the Liver Clinic at the Base Hospital here (10 months and counting so far)! My four week blood tests came back HCV undetectable :)

    Have a great New Year and I look forward to hearing your results.

    Cheers Lynne

    YMMV

    31 December 2015 at 5:55 am #7607
    Avatar photoChejai
    • Guardian Angel
    • ★★★★★
    @chejai

    Hi Sonix thanks for posting your Tx details, especially previous symptoms – i have all of those:) I’m G3a but still interested in hearing how you go. Waiting for my meds to arrive – email 18/12/15 – said 3-4 weeks!

    Good Luck!

    QLD Australia ☀️
    G3a HCV 35 yrs Tx naive
    Started Sof/Dac 13/01/16

    Dec ’15
    AST 70
    ALT 89
    GGT 124
    Fibroscore 8.5
    F1-F2
    13 Feb’16 VL UND #woohoo!
    AST 24
    ALT 26
    GGT 50H

    31 December 2015 at 6:01 am #7608
    Avatar photosonix
    • Guardian Angel
    • ★★★★★
    @sonix
    poodle wrote:

    Hi Sonix Thanks for posting all the info. Iam also 1a 30 plus years. Can I ask why you decided on sof/dac and not sof/led ? Cheers, and Happy new year. Jill

    Partly because of the $700 price difference, but confirmed by Dr James that Sof/Dac should be at least as effective as Sof/Led, and possibly better but trials have been small so far.
    And yes, you need a script.

    Happy New Year to all!

    M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
    SVR4 at 7Apr16 ALT 22 AST 22
    SVR12 at 9Jun16 ALT 23 AST 25
    Melbourne, Australia

    31 December 2015 at 6:57 am #7609
    SueHealth
    • Topics: 1
    • Replies: 5
    • Total: 6
    • Novice
    • ★
    @suehealth

    Hi Sonix,

    Thanks for your info and experiences I am in Melb too! I have Geno 1a, I have been on Sof/led for 1 month
    10 days and have been suffering with anxiety for years.I have noticed I am less anxious and my energy is better
    in that I can do an exercise program though I still need to rest in the afternoon.

    Have a Great New Year
    SueHealth

    31 December 2015 at 9:17 am #7612
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Hey sonix, good to hear your story and great news that you’re handling tx so well and seeing those improvements. I’m also 1a (27 yrs) and have had all those hep symptoms, complicated by hormonal problems and chronic pain (plus recently an at least semi-failed shoulder op) Awesome that so many have been relieved for you.

    I will be on sof/dac as well from tomorrow, Dr J’s rationale was the same he as advised you – could well be better than Led due to a slightly higher logkill ratio (albeit small trial sample as you say)

    All the best for the rest of your treatment, and wishing everyone here a great start to a healthy new year. We couldn’t have been given a better chance :)

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    31 December 2015 at 9:39 am #7614
    Avatar photoCJ
    • Guardian Angel
    • ★★★★★
    @cj

    Good luck Sonix.
    Hope the new year brings you SVR :)

    Hey zhuk,
    Tomorrow! exciting! hope it goes well for you. :cheer:
    x

    J the young dragon slayer is:
    HepC 1a since birth
    Male aged 15
    VL 2000000
    Started Twinvir/ 10-11-15-then Sof/led.
    NO sides so far !
    after one week VL : 37
    after 4 wks VL : UND !
    EOT 2/2/16 UND.!
    4 wks. post tx results….pending….
    7/3/16 VL result : 4 week post tx: SVR !
    12 weeks SVR !
    24 wks SVR yeeaa!!

    31 December 2015 at 9:45 am #7617
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Hey cheers Cindi!

    Been a long time coming heh, but I am so ready for it now :)

    7-day phone alarm is set lol

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    31 December 2015 at 12:31 pm #7637
    Avatar photoisaing4
    • Guardian Angel
    • ★★★★★
    @isaing4

    Hi Sonix,
    Thanks for sharing your tx story!
    Happy for your improvements. :lol:
    Undetectable as soon as possible and stay so forever.
    Happy New Year to all!

    HCV since I don’t know. Diagnosed in 2010.
    GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
    started 12 wks Twinvir on 06.12.2015. Feeling great and grateful 🙂
    virus not detected 06.02.2016 & SVR24
    isaing4@gmail.com

    31 December 2015 at 12:58 pm #7639
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Hi Sonix, Warm wishes for the best possible outcome from another 1a

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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