Dan's Twinvir story

This topic has 360 replies, 38 voices, and was last updated 7 years, 7 months ago by LondonGirl.

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2 February 2016 at 5:51 pm #11021
Enkel
- Topics: 16
- Replies: 293
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- Guardian Angel
@enkel
I really dont trust your first hospital results. Now you are ok. There is no need for more than 12 weeks.

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
2 February 2016 at 6:16 pm #11022
Dan
- Topics: 6
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- Guardian Angel
@dan
Thank you.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
2 February 2016 at 11:36 pm #11043
Dan
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- Guardian Angel
@dan
One part of me saying to stop now or 12 weeks, the other to add 4 more weeks, to be sure.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
2 February 2016 at 11:49 pm #11045
Enkel
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- Total: 309
- Guardian Angel
@enkel
12 weeks are enough and neccesary. You are treatment naive. Even naive cirrhotic patient for 24 weeks and 12 weeks had the same cure rate 97%

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
3 February 2016 at 2:05 am #11054
Sirchinenge
- Topics: 7
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- Total: 267
- Guardian Angel
@sirchinenge
Enkel 12 is not UD you constantly saying its so does not make it any more true.

Dan. Great news.

No great advice on my end if you continue or not I agree at week 8 the evidence suggests you will
remain UD now and post treatment.

I am continuing as I’d all ready bought the medications I thought Id make use of four extra weeks

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
3 February 2016 at 12:19 pm #11093
Enkel
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@enkel
Yes S,

12 is not UND but is <= LLOQ and if someone is on GILEAD Harvoni and being 12 at EOT still have the 97% cure rate. I assume that twinvir is the exact copy of Harvoni. Dan is treatment naive and 8 weeks for him have still 97 cure rate. 12 weeks are enough

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
4 February 2016 at 7:07 pm #11176
isaing4
- Topics: 2
- Replies: 237
- Total: 239
- Guardian Angel
@isaing4
Hi Dan,
Wonderful news!
I am so happy for you!

HCV since I don’t know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful 🙂
virus not detected 06.02.2016 & SVR24
isaing4@gmail.com
4 February 2016 at 10:32 pm #11183
Dan
- Topics: 6
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- Total: 203
- Guardian Angel
@dan
Thanks

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
5 February 2016 at 4:54 am #11210
Gaj
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- Guardian Angel
@gaj
Hi Dan,

Congratulations on reaching UND! That must be a wonderful feeling.

I’m not sure I can help with whether to extend treatment, the statistics say that 12 weeks should be enough. You need to weight up side effects vs any extra peace of mind a further 4 weeks would give.

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
5 February 2016 at 1:39 pm #11252
Dan
- Topics: 6
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- Total: 203
- Guardian Angel
@dan
9.5 weeks now

Based on my 8 week blood result, I’ve decided to complete my 12 weeks tx and not to add any extra weeks.

I feel that sx increased again after 9 weeks mark. I hope that all of them will go away after the treatment.

Not long to go now, 19 magic pills.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
6 February 2016 at 3:30 am #11283
Greedfighter
- Topics: 28
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- Total: 610
- Guardian Angel
@greedfighter
Hi Dan,

Congratulations on being UD!!
6 February 2016 at 6:09 am #11297
Chejai
- Topics: 5
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- Guardian Angel
@chejai
Congratulations Dan on the UND , it seems to have given you peace of mind. Probably a good idea you’ve decided to complete the 12 weeks, there’s not enough known yet about the DAA’s and the length of Tx. It might be like taking a course of antibiotics, you have to complete the ‘course’ not stop when you feel better. Obviously Gilead etc. are trying to find the shortest and most successful length of Tx to save on their subsidies, so there’s lots of data being gathered.

Hope the rest of your Tx goes well

QLD Australia ‚òÄÔ∏è
G3a HCV 35 yrs Tx naive
Started Sof/Dac 13/01/16

Dec ’15
AST 70
ALT 89
GGT 124
Fibroscore 8.5
F1-F2
13 Feb’16 VL UND
AST 24
ALT 26
GGT 50H
9 February 2016 at 2:00 am #11553
Dan
- Topics: 6
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- Total: 203
- Guardian Angel
@dan
Week 10 tomorrow.

All the same sx. Started to get bowel problems from 9 weeks mark.

The other issue is a worry, should I go for extra 4 weeks or no, which I carried for a while. I wasn’t like that 2 years ago and couldn’t understand some people, who couldn’t make their mind up.

I came down last week, until the new topic, that Led is not the same quality, potentially.

I’m glad that some of you are optimistic and put me right. ))

I also get support messages to go for it and what’s the point, just complete 12 weeks.

It is so hard.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
17 February 2016 at 11:39 pm #12126
Dan
- Topics: 6
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- Total: 203
- Guardian Angel
@dan
Week 11.

Just a week to go. I stayed away from the forum for few days and noticed that my anxiety improved a lot. Over the weekend I got done a lot of staff around the house, the energy levels have gone up. During the week, still tired after work.

Still get lightheaded, but for some reason stopped worrying about it too much, which is a positive sign.

I’m planning to get the next VL blood test at 4 weeks EOT.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
18 February 2016 at 6:09 am #12157
Greedfighter
- Topics: 28
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- Total: 610
- Guardian Angel
@greedfighter
I’m really happy for you Dan! I’m going to get tested at 6 weeks and pray I am undetected.

My energy level keeps increasing too.
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