Dan's Twinvir story

This topic has 360 replies, 38 voices, and was last updated 7 years, 7 months ago by LondonGirl.

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3 December 2015 at 12:16 pm #5169
CJ
- Topics: 10
- Replies: 362
- Total: 372
- Guardian Angel
@cj
Hey Dan,
You may find your eczema settles down a lot once the drugs start doing their job & wiping out the virus.
Hope so.
x.

J the young dragon slayer is:
HepC 1a since birth
Male aged 15
VL 2000000
Started Twinvir/ 10-11-15-then Sof/led.
NO sides so far !
after one week VL : 37
after 4 wks VL : UND !
EOT 2/2/16 UND.!
4 wks. post tx results….pending….
7/3/16 VL result : 4 week post tx: SVR !
12 weeks SVR !
24 wks SVR yeeaa!!
3 December 2015 at 12:40 pm #5175
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Will be interested to know what they say at the hospital Dan .

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
3 December 2015 at 10:26 pm #5192
Enkel
- Topics: 16
- Replies: 293
- Total: 309
- Guardian Angel
@enkel
Did you started the meds?

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
3 December 2015 at 11:13 pm #5197
Dan
- Topics: 6
- Replies: 197
- Total: 203
- Guardian Angel
@dan
Yes. First day today.. The tablets are huge , but swallowed it without problems .

I feel a bit sleepy now, but mostly this is due to lack of sleep and chest pain last night.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
4 December 2015 at 11:28 pm #5250
zhuk
- Topics: 5
- Replies: 543
- Total: 548
- Guardian Angel
@zhuk
Good to hear Dan! Onward and upward from here

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
5 December 2015 at 9:10 am #5276
parvez
- Topics: 3
- Replies: 23
- Total: 26
- Treatment Warrior
@parvez
Hope you will get well very soon!!

Alimul Razi
Reg. Pharmacist
Brand Manager (Anti-viral)
Marketing Strategy Department
Incepta Pharmaceuticals Ltd
Phone: +8801712353971 (Viber, Whats App, we Chat), +8801713380056
Email: alimul@inceptapharma.com
Approved by Buyers Club
http://fixhepc.com/forum/daa-access/435-incepta-pharmaceuticals-
5 December 2015 at 5:22 pm #5291
Jolie
- Topics: 5
- Replies: 126
- Total: 131
- Guardian Angel
@jolie
smooth sailing Dan

Geno 3, Fibro 8.7 pKA, tx experinced in 2005 – Peg/Riba, relapsed.
Started tx 1/12/2015 with Indian Sofo & Chinese Dac.
5 weeks result all normal, ALT 18 – down from ALT 73 at the start of tx.
5 weeks HCV PCR RNA – UND. – down from 2 ML
9 weeks HCV PCR RNA – UND.
6 December 2015 at 4:17 pm #5323
Dan
- Topics: 6
- Replies: 197
- Total: 203
- Guardian Angel
@dan
Day 4 today. My sleep is ok, but I get pumping sensations in the evening, possibly Sof reaction.
Still feel a bit dizzy at times.
Started to get interesting taste in the mouth.
My skin is really bad at the moment. Itchy and burning, not sure what to do.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
6 December 2015 at 4:29 pm #5324
Paul-Jarman-facebook
- Topics: 8
- Replies: 373
- Total: 381
- Guardian Angel
@paul-jarman-facebook
Whatever is going on Dan will pass, I know that can sound a bit trite but it does. Your massacaring billions of viral cells, a war is going on and you body is the battlefield. JUst behave normally and unless something seems extreme don’t worry too much about it but by all means do tell us please. Most people seem to have something going on during treatment.

cheers

Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated

GT 3 – about 28 yrs with HCV
6 December 2015 at 4:32 pm #5325
Gaj
- Topics: 29
- Replies: 1,402
- Total: 1,431
- Guardian Angel
@gaj
Hi Dan,

I found sorbolene moisturiser (plain, unscented) very effective when I was on Peg/Riba and had bad itching and skin irritation but not certain about using if you have eczema?

Not sure what you mean by “pumping sensations”? Do you take the meds in evening?

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
6 December 2015 at 6:27 pm #5334
Enkel
- Topics: 16
- Replies: 293
- Total: 309
- Guardian Angel
@enkel
What is the best time to take the meds? Morning or Evening?

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
6 December 2015 at 7:14 pm #5335
Dan
- Topics: 6
- Replies: 197
- Total: 203
- Guardian Angel
@dan
I take them first thing in the morning.30 minutes before my breakfast.

By pumping sensations, I mean the pulsating feeling in the body.

I went shopping today for an hour. After that I feel so tired.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
6 December 2015 at 7:23 pm #5336
Enkel
- Topics: 16
- Replies: 293
- Total: 309
- Guardian Angel
@enkel
I have that pumping sensation as a earthquake body sensation, as if my body is imitating the heartbeat. I have concluded that it is a mis-coordination of vagus nerve which connect all the organs. Due to the damage of HCV on vagus nerve in liver and other parts, the signals get mixed. The signal of heartbeat may go to the musculature of intestine.

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
7 December 2015 at 4:27 am #5350
Gaj
- Topics: 29
- Replies: 1,402
- Total: 1,431
- Guardian Angel
@gaj
Hi Dan,

I was wondering if the effect you describe was occurring just after you took the meds so a reaction to them but it seems not. I’m thinking maybe the pumping/pulsating feeling is what I and a few others describe as a “speedy” feeling? If so mine seems to have reduced a little in the third week.

Enkel,

Not sure there is a best time to take the meds. I started taking mine before breakfast like Dan in case they effected my sleep but knowing that if they made it difficult to do work etc during the day then I could move the time say an hour a day until I was taking them in the evening. But the morning seems fine and hasn’t caused noticeable problems so I just keep taking before breakfast. ( I also take two doses of ribavarin each day after breakfast and evening meal as you need a full stomach for those.)

G

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
7 December 2015 at 7:10 am #5364
CJ
- Topics: 10
- Replies: 362
- Total: 372
- Guardian Angel
@cj
J takes his led/sof with breakfast, with no ill affects.
x

J the young dragon slayer is:
HepC 1a since birth
Male aged 15
VL 2000000
Started Twinvir/ 10-11-15-then Sof/led.
NO sides so far !
after one week VL : 37
after 4 wks VL : UND !
EOT 2/2/16 UND.!
4 wks. post tx results….pending….
7/3/16 VL result : 4 week post tx: SVR !
12 weeks SVR !
24 wks SVR yeeaa!!
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