Dan's Twinvir story

This topic has 360 replies, 38 voices, and was last updated 7 years, 7 months ago by LondonGirl.

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18 February 2016 at 5:31 pm #12178
Enkel
- Topics: 16
- Replies: 293
- Total: 309
- Guardian Angel
@enkel
Twinvir is the best generic.

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
19 February 2016 at 4:47 pm #12261
darbara
- Topics: 6
- Replies: 166
- Total: 172
- Guardian Angel
@darbara
if there a difference in the generics ?

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
20 February 2016 at 4:59 am #12307
Greedfighter
- Topics: 28
- Replies: 582
- Total: 610
- Guardian Angel
@greedfighter
I have had few side effects on Twinvir, but I have not been tested yet for VL. But if I was Enkel I would feel the same way…2 weeks and he is undetected! His results are part of the reason I chose Twinvir.
21 February 2016 at 4:36 pm #12387
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Hey GF,
Will the 6 week test be your 1st since starting tx? A $100 says you’re <15 or UND.

On Twinvir, it's the real deal. Made from Mesochem APIs (unless my brain fog has returned) and we all know Mesochem is the stuff.

I will be the first to admit I am not very familiar with the Indian products. The main reason being it was never necessary, since Incepta and Rachel were doing such a great job getting quality, affordable tx to people in the U.S.
M

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
21 February 2016 at 5:13 pm #12388
Greedfighter
- Topics: 28
- Replies: 582
- Total: 610
- Guardian Angel
@greedfighter
Hi Mike,

Yes, the 6 week test will be the first. I will be going next Saturday.
21 February 2016 at 5:17 pm #12389
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
You going to take me up on my bet??
The crap is gone, my man!

M

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
21 February 2016 at 6:00 pm #12391
Greedfighter
- Topics: 28
- Replies: 582
- Total: 610
- Guardian Angel
@greedfighter
No way!

I appreciate your encouragement!

I feel really good! I’m hoping I come back undetected, or close to it.

I am a little spooked because I eat grapefruit every morning, and just read somewhere they are recommending against it, only because nobody knows yet if it has an effect on Sof/Led. I am switching to oranges!

But I have my fingers crossed :
21 February 2016 at 6:05 pm #12393
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Hey,
My wife squeezes two grapefruit for my morning juice everyday. I washed my medicine down with it. Been at it since my diagnosis almost 3 years ago.
You’re good!
M

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
21 February 2016 at 6:17 pm #12394
Greedfighter
- Topics: 28
- Replies: 582
- Total: 610
- Guardian Angel
@greedfighter
That’s good to hear! Thanks for sharing that!
22 February 2016 at 12:08 pm #12434
sonix
- Topics: 7
- Replies: 158
- Total: 165
- Guardian Angel
@sonix
As mentioned elsewhere, grapefruit is an inhibitor for CYP3A4 enzyme which metabolises Daclatavir. Twinvir is Ledipasvir and Sofosbuvir so I’m guessing you’re good.

M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia
22 February 2016 at 10:52 pm #12461
Dan
- Topics: 6
- Replies: 197
- Total: 203
- Guardian Angel
@dan
Hi.
Had my GP appointment today and was told my 7 weeks blood results.
I’m low on Vit D, GP told me to take some until summer.
As I already mentioned, the VL was detected at that time, but doctor showed me the comments ” Unable to quantify, antibodies detected”.

What does this mean?

He gave me the referral for EOT Viral load blood test.

Do I need an ultrasound or fibroscan at EOT?

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
23 February 2016 at 12:34 am #12463
darbara
- Topics: 6
- Replies: 166
- Total: 172
- Guardian Angel
@darbara
This means that you have HCV antibodies which all of us have SVR or no and will always have but your VIRAL LOAD is so low that it cant be detected. No u dont need ultrasound or fibroscan at EOT maybe later on if you want to.
My viral load after 4 weeks was <25 which my doc said is undetected so the treatment is working next test for me is EOT 12 WEEKS.
Please read this its very informative:
http://hepatitiscnewdrugresearch.com/hcv-viral-load-test.html

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
23 February 2016 at 12:41 am #12464
darbara
- Topics: 6
- Replies: 166
- Total: 172
- Guardian Angel
@darbara
The Bottom Line:
In the past when using interferon-based treatments, a detectable viral load at EOT meant that treatment wouldn’t be successful. With Harvoni-based HCV treatment, this rule no longer applies—a detectable viral load at EOT DOES NOT mean that treatment will not be successful. – See more at: http://hepatitiscnewdrugresearch.com/hcv-viral-load-test.html#sthash.5M2h5HzI.dpuf

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
23 February 2016 at 12:57 am #12466
Dan
- Topics: 6
- Replies: 197
- Total: 203
- Guardian Angel
@dan
Thanks darbara. I’m not worried about the EOT result, at least not yet. ‘

Will have a read later.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
23 February 2016 at 2:43 am #12470
sonix
- Topics: 7
- Replies: 158
- Total: 165
- Guardian Angel
@sonix
Dan wrote:

As I already mentioned, the VL was detected at that time, but doctor showed me the comments ” Unable to quantify, antibodies detected”.

What does this mean?

I would take this to mean HCVDNA detected but

M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia
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