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12 November 2015 at 3:32 pm #3748
Furthermore – we all know that a successful tx is not about the millions of virions that go down in the first few weeks, it is about eliminating the few hangers-on that are left.
I watched that video on ribavirin resistance a ton of times and I am not convinced that ribavirin resistance makes it not worth while to use. On the contrary, there is data from the ION2 and the SIRIUS trials that show that it makes a difference in some situations. My thinking is that a DAA is a one trick pony. It has one method of action. If a virion mutation is not susceptible to that action then you can swamp it with that DAA till the cows come home and that mutation will just keep replicating and repopulate your viral load. Ribavirin, on the other hand, has more than one method of action. It is not as fast or dramatic as a DAA but it can still nail that mutant virion when the other DAAs have become useless. Which is exactly what you need to keep the pressure on when you have a few stragglers that just keep hanging on. So, in my humble opinion, I think that the role of ribavirin when used with the DAAs is underrated.
dt
12 November 2015 at 4:15 pm #3749How about Asunaprevir? Could this be added to the mix?
Virus not detected from 14.10.2015
12 November 2015 at 4:49 pm #375212 November 2015 at 4:50 pm #3753Good post. Think so too is what I meant…
12 November 2015 at 8:31 pm #3759Plenty of time for you to get to UND yet Em. Some don’t get there until 9 or 10 weeks into a 12 week treatment and still achieve SVR.
12 November 2015 at 11:28 pm #3765hi Em,
Yes, I’d be a bit upset too, at the same time your liver functions & other blood tests were very good, so I believe it is only a matter of waiting a bit longer for SVR.
As you said you could have F3 fibrosis & also you’re tx experienced, I’m in the same situation, so due to this we probably need longer then 12 weeks tx & even add Riba at some point?
I was wondering if one can add Riba half way through the tx ? to assure best results ?
jolie xxxxx
Geno 3, Fibro 8.7 pKA, tx experinced in 2005 – Peg/Riba, relapsed.
Started tx 1/12/2015 with Indian Sofo & Chinese Dac.
5 weeks result all normal, ALT 18 – down from ALT 73 at the start of tx.
5 weeks HCV PCR RNA – UND. – down from 2 ML
9 weeks HCV PCR RNA – UND.13 November 2015 at 1:34 am #3773Thanks for the well wishes and encouragement everyone. The long way round is okay with me. Riba? I’m still not sold on it for geno 1s? However would be keen on adding simprevir if anyone knows where. Em
13 November 2015 at 1:59 am #3774[video]https://www.youtube.com/watch?v=72r32bceDzg[/video]
http://www.alibaba.com/trade/search?fsb=y&IndexArea=product_en&CatId=&SearchText=simeprevir
13 November 2015 at 2:21 am #377513 November 2015 at 2:30 am #377613 November 2015 at 2:33 am #3777Jolie -there was somebody on medhelp who added riba for the last 15 weeks of her 24 week tx. She got to SVR.
dt13 November 2015 at 2:40 am #3779Thanks Joy, so throw away the interferon and keep the riba and simp lol, that could work?
13 November 2015 at 2:43 am #3780Is it really as simple as buying API on Alibaba ?
There is one API I have my sight on for geno 3 to add to the mix sold in China, I mean is that all it takes ?
I did check the company looks very big & reputable making medicinal API.sBecause if it is as simple anyone can make their own meds…..& mix anything they like
Geno 3, Fibro 8.7 pKA, tx experinced in 2005 – Peg/Riba, relapsed.
Started tx 1/12/2015 with Indian Sofo & Chinese Dac.
5 weeks result all normal, ALT 18 – down from ALT 73 at the start of tx.
5 weeks HCV PCR RNA – UND. – down from 2 ML
9 weeks HCV PCR RNA – UND.13 November 2015 at 2:47 am #378313 November 2015 at 2:59 am #3786 -
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