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  • #3748
    Avatar photodointime
    • Guardian Angel
    • ★★★★★
    @dointime

    Furthermore – we all know that a successful tx is not about the millions of virions that go down in the first few weeks, it is about eliminating the few hangers-on that are left.

    I watched that video on ribavirin resistance a ton of times and I am not convinced that ribavirin resistance makes it not worth while to use. On the contrary, there is data from the ION2 and the SIRIUS trials that show that it makes a difference in some situations. My thinking is that a DAA is a one trick pony. It has one method of action. If a virion mutation is not susceptible to that action then you can swamp it with that DAA till the cows come home and that mutation will just keep replicating and repopulate your viral load. Ribavirin, on the other hand, has more than one method of action. It is not as fast or dramatic as a DAA but it can still nail that mutant virion when the other DAAs have become useless. Which is exactly what you need to keep the pressure on when you have a few stragglers that just keep hanging on. So, in my humble opinion, I think that the role of ribavirin when used with the DAAs is underrated.

    dt

    #3749
    Avatar photoNadia
    • Guardian Angel
    • ★★★★★
    @nadia

    How about Asunaprevir? Could this be added to the mix?


    Virus not detected from 14.10.2015

    #3752
    Avatar photoLife
    • Guardian Angel
    • ★★★★★
    @life

    Huhmn think so DT!

    #3753
    Avatar photoLife
    • Guardian Angel
    • ★★★★★
    @life

    Good post. Think so too is what I meant…

    #3759
    Avatar photoAlsdad
    • Guardian Angel
    • ★★★★★
    @alsdad

    Plenty of time for you to get to UND yet Em. Some don’t get there until 9 or 10 weeks into a 12 week treatment and still achieve SVR.

    #3765
    Avatar photoJolie
    • Guardian Angel
    • ★★★★★
    @jolie

    hi Em,
    Yes, I’d be a bit upset too, at the same time your liver functions & other blood tests were very good, so I believe it is only a matter of waiting a bit longer for SVR. :)
    As you said you could have F3 fibrosis & also you’re tx experienced, I’m in the same situation, so due to this we probably need longer then 12 weeks tx & even add Riba at some point?
    I was wondering if one can add Riba half way through the tx ? to assure best results ?
    jolie xxxxx


    Geno 3, Fibro 8.7 pKA, tx experinced in 2005 – Peg/Riba, relapsed.
    Started tx 1/12/2015 with Indian Sofo & Chinese Dac.
    5 weeks result all normal, ALT 18 – down from ALT 73 at the start of tx.
    5 weeks HCV PCR RNA – UND. – down from 2 ML
    9 weeks HCV PCR RNA – UND.

    #3773
    Avatar photoemilio
    • Guardian Angel
    • ★★★★★
    @emilio

    Thanks for the well wishes and encouragement everyone. The long way round is okay with me. Riba? I’m still not sold on it for geno 1s? However would be keen on adding simprevir if anyone knows where. Em

    #3774
    Avatar photoklhilde
    • Guardian Angel
    • ★★★★★
    @klhilde

    [video]https://www.youtube.com/watch?v=72r32bceDzg[/video]

    http://www.alibaba.com/trade/search?fsb=y&IndexArea=product_en&CatId=&SearchText=simeprevir

    :unsure:

    #3775
    Avatar photoemilio
    • Guardian Angel
    • ★★★★★
    @emilio

    Thanks mate

    #3776
    Avatar photoJoy
    • Guardian Angel
    • ★★★★★
    @joy

    Em, Simeprevir is already on the PBS.

    #3777
    Avatar photodointime
    • Guardian Angel
    • ★★★★★
    @dointime

    Jolie -there was somebody on medhelp who added riba for the last 15 weeks of her 24 week tx. She got to SVR.
    dt

    #3779
    Avatar photoemilio
    • Guardian Angel
    • ★★★★★
    @emilio

    Thanks Joy, so throw away the interferon and keep the riba and simp lol, that could work?

    #3780
    Avatar photoJolie
    • Guardian Angel
    • ★★★★★
    @jolie

    Is it really as simple as buying API on Alibaba ?
    There is one API I have my sight on for geno 3 to add to the mix sold in China, I mean is that all it takes ?
    I did check the company looks very big & reputable making medicinal API.s

    Because if it is as simple anyone can make their own meds…..& mix anything they like


    Geno 3, Fibro 8.7 pKA, tx experinced in 2005 – Peg/Riba, relapsed.
    Started tx 1/12/2015 with Indian Sofo & Chinese Dac.
    5 weeks result all normal, ALT 18 – down from ALT 73 at the start of tx.
    5 weeks HCV PCR RNA – UND. – down from 2 ML
    9 weeks HCV PCR RNA – UND.

    #3783
    Avatar photoJoy
    • Guardian Angel
    • ★★★★★
    @joy

    You mean it only comes as a threesome? :blink:

    #3786
    Avatar photoemilio
    • Guardian Angel
    • ★★★★★
    @emilio

    I think so Joy so approved with IFN/Riba as a tripple. Think i could take great pleasure smashing the ampules of IFN lol. Dont think you can obtain or buy separately

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