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Hi all,
While obviously a bit disappointed I’m not disheartened thanks to all my wonderful friends here who help keep me strong and focused on the future. As others have said Gt3 can be more difficult to cure particularly if you have cirrhosis but with the new medications steadily being advanced and targeted at this problem there will be other opportunities to clear this horrible virus, hopefully very soon.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Gaj
I’m sorry to read that the virus is detected again. The GT3a virus seems to have mutated into the boomerang genotype, as it keeps on coming back. However, SOF + VEL looks like a promising weapon to eliminate it. The most problematic NS5A RAV for this combo appears to be the Y93H variant, so hopefully your baseline tests will not find it.
Stay positive and patient. I have no doubt that you’ll eventually beat it with persistence and determination.
Best Wishes
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9 
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Really sorry to hear this GAJ
Hopefully the blood work you gave them can help you determine what ravs you have so that you can figure out what would be your next tx option is. Hopefully some of these new drugs coming out soon can eradicate these buggers.
I hope you get some answers to what direction your next move is very soon.
Hi Gaj, so sorry about your blood work. The newer drugs sound promising. Wishing you the best with the next therapy. Thank you for all the support you have given to others.
Thanks Jim, Sof/Vel certainly looks promising based on the clinical trial results for Gt3s like us.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
ah Gaj,
What a sad thing to hear, I’ve been offline for quite a while, just logged on & saw this, really sorry .I know you’re so strong, & don’t let things faze you much, you were always there for me & J when he was treating, thank you so much for that.
Keep up that strong attitude, you’ll beat this.The different oral drugs being developed now , makes that hope pretty real now
I’m going to log in more often to see how you go.
Good luck my friend.Love Cindi x
”Hit wrote:….I’m wondering if all G3s fail Sof/Dac treatment.
No, on the contrary the overwhelming majority are successful in achieving SVR. While G3 is often a bit more difficult to treat than the other genotypes, Sof/Dac has been the most effective treatment available for this genotype so far.
The main problems with us G3s seem to be related to cirrhosis, previous Tx, VL and length of Tx. I score very poorly on the first three so went into 24 week Tx knowing I only had a 80% likelihood of success based on previous studies. While I didn’t achieve SVR my overall health has improved in leaps and bounds putting me in a good position to do so next time.
In your case with F0, naive and low VL you had a 96-97% chance based on trial data, then you extended Tx to 16 weeks which helps even more. I understand how nervous you must feel approaching SVR but you have done everything possible and are in an excellent position to succeed. I look forward to cheering when you cross the line!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Gaj, thank you for being so selfless and reassuring with your response…
Id like to take this op to thank you for alway being so giving re: this forum…& I have little doubt, once you kick this virus, there won’t be a dry eye in the house.
You take care
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