For patients with Hepatocellular Carcinoma (HCC) the options are limited. Caught early enough RadioFrequency Ablation (RFC), TransArterial ChemoEmbolisation (TACE) or surgical resection can potentially be curative. For some patients with advanced disease a liver transplant may be an option, but what about everyone…
Friday, 03 August 2018 01:36

U=U - Undetectable = Untransmissable

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Strictly speaking, this relates to HIV but it also applies the Hepatitis C.Undetectable = UntransmissableGet tested, get treated, get cured! https://ashm.org.au/HIV/UequalsU/
News FlashMAVIRET® (glecaprevir/pibrentasvir) was listed on the PBS in Australia today. AbbVie is pleased to announce that MAVIRET is to be listed on the PBS on 1 August 2018 for the treatment of chronic hepatitis C virus (HCV) infection in adults. MAVIRET…
Tuesday, 24 July 2018 14:43

Hep C Awareness - Images and Poster

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Most of the messaging to people about Hepatitis C is boring with as much cut through as a blunt knife through a block of titanium. If you were born between A and B, if this, if that, etc. It's time to change…
The other day, on Facebook, I witnessed a patient, looking for advice, be given some very poor advice. Where poor = wrong and potentially lethal. I provided some accurate commentary which was deleted, leaving a whole lot of no doubt well-meaning, but…
They say (who are they anyway?) "If it seems to good to be true it probably is". When it comes to generic Hepatitis C medication some people struggle with the idea that something like Harvoni® with a list price of $94,000 USD…
So you've made it! SVR at last. What now? Here is a slideset from Clinical Care Options where Ira M. Jacobson, MD, and Paul Y. Kwo, MD, review optimal management of patients with HCV who have achieved SVR, including recommendations for HCV RNA and HCC monitoring. These doctors are…
With HIV we observered that if we use 1 drug resistance develops rapidly, with 2 drugs it is slower, and with 3 drugs it virtually never happens, so it does not come as any great surprise that combining an NS3/4A drug with…
Highlights Ravidasvir is a new NS5A inhibitor for HCV. Sofosbuvir + Ravidasvir with or without RBV has achieved very high SVR rates. Results are comparable for both patients with and without cirrhosis. Serious adverse events were noticed in very few treated patients.…
A quick note on how to take your DAA medication. Read the package insert and follow the instructions with respect to with (or without) food. For example, for Vosevii Administration with food enhances the oral bioavailability of sofosbuvir, velpatasvir, and voxilaprevir. Relative…
Tuesday, 19 December 2017 09:56

HCV retreatment 101 in plain English - Part 1

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Any SVR rate <100% means a small number of people will not attain SVR. A 95% SVR means for every 20 people on generic treatment 1 patient will relapse. Back in early 2016 I came across an excellent article from Dr Jordan Feldwas…
Friday, 01 December 2017 04:12

We can all make a difference...

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Once upon a time, there was an old man who used to go to the ocean to do his writing. He had a habit of walking on the beach every morning before he began his work. Early one morning, he was walking…
The combination of Sovaldi (Sofosbuvir) and Daklinza (Daclatasvir) was the world's first pan-genotypic Hepatitis C treatment. In the USA and Europe the $140,000 price tag of this combination means it has seen relatively little use, but in the world of generics it…
Monday, 20 November 2017 21:27

What happens when you finish your Hep C treatment?

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Recently I have been getting a number of enquires from patients who have just finished their tablets, all asking the same questions, so here is a quick primer. If you are looking for this sort of information you will find a lot…
Thursday, 16 November 2017 20:50

71% decrease in cancer rate for Hep C patients with SVR

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Some time ago we saw some very bad science published. This suggested that treating Hepatitis C confers no benefits. While experts around the world expressed their firm view this was complete and utter rubbish here is something simple to understand. Get treated,…
KUALA LUMPUR/GENEVA – 13th November 2017 – Malaysian pharmaceutical company Pharmaniaga Logistics Sdn Bhd (Pharmaniaga), Egyptian pharmaceutical company Pharco Pharmaceuticals (Pharco) and non-profit research and development organization Drugs for Neglected Diseases initiative (DNDi) have signed a collaboration agreement to supply a new…
We have the power to FixHepC, but the real question is... Do we have the willpower? This was how Dr James Freeman ended his presentation at the World Hepatitis Summit in Brazil. You can watch the full presentation on YouTube. In essence,…
Hepatitis C is a disease that can make you feel old before your time. While there is no doubt that treatment with the new generation of direct acting antivirals like Harvoni is by far the best option this is not available to…
About 1 in 100 people, from all walks of life, have Hepatitis C so it is pretty common. Because it is a highly stigmatised disease, linked in the public mind to IV drug use, most patients choose to keep their diagnosis confidential.…
Just out of embargo for AASLD 2017 is the rather innocuous sounding Abstract 1078 which says, in brief, that these generic DAAs are inarguably proven the same as the originator DAAs.Bioequivalent pharmacokinetics for generic and originator Hepatitis C Direct Acting Antivirals Andrew M.…
Switzerland has just announced that all limitations on access to the new DAAs will be abolished allowing treatment for all. Great news for Swiss patients. Here is an article from the Swiss Hepatitis C Association about it. If you are not lucky…
Wednesday, 20 September 2017 01:52

The Effects of Hepatitis C on Your Body

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What exactly is chronic HCV? In a nutshell, it refers to ongoing inflammation of your liver. But it can lead to symptoms throughout your body. Over time, living with this condition can cause your body to be especially vulnerable to serious health…
Tuesday, 29 August 2017 04:12

Access Versus Praccess

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Last week there was some celebrations after Under pressure, Gilead expands Sovaldi licensing deal to four middle-income countries. So great news, right? Not exactly, because in order for a country to have PRACTICAL ACCESS the product needs to be registered for sale…
By Priti Krishtel Last week, the FDA approved AbbVie’s Mavyret—a new hepatitis C virus (HCV) drug that treats all genotypes of the disease and cures more than 90% of patients within just 8 weeks of treatment. This has been reported as a…

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