Dan's Twinvir story

This topic has 360 replies, 38 voices, and was last updated 8 years ago by LondonGirl.

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11 December 2015 at 1:58 am #5857
Nadia
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- Guardian Angel
@nadia
Just realised that my shortness of breath has completely dissapeared now.

Virus not detected from 14.10.2015
11 December 2015 at 2:43 am #5865
Dan
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- Replies: 197
- Total: 203
- Guardian Angel
@dan
That is great.

I was doing some gentle exercises tonight and steam bath to clear my chest.

Hopefully will sleep at night.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
12 December 2015 at 5:49 pm #6081
Dan
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- Total: 203
- Guardian Angel
@dan
Day 10.
Eczema is still really bad. Managed to see dermatologist today, who prescribed stronger steroid creams and antibiotics, clarithromycin. On the drug comparison site said that there could be interaction. I just wonder if I m ok to take one tablet in the evening, as I take Twinvir in the morning.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
12 December 2015 at 6:50 pm #6084
Dr James
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- Guardian Angel
@fixhepc
Twinvir (Sof/Led) does not interact with clarithromycin so that will be fine:

You can check here: http://www.hep-druginteractions.org/checker

And the result is attached:

YMMV
12 December 2015 at 7:01 pm #6085
Nadia
- Topics: 1
- Replies: 105
- Total: 106
- Guardian Angel
@nadia
Hi Dan,
Maybe you could try just the cream first and hopefully that will do the trick without the tablets?

Virus not detected from 14.10.2015
12 December 2015 at 8:19 pm #6088
Dan
- Topics: 6
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- Total: 203
- Guardian Angel
@dan
Thanks Nadia and Dr James.
I’ll try just the creams until Monday and see what happens.

Feel a bit brighter this afternoon

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
13 December 2015 at 2:21 am #6119
Dan
- Topics: 6
- Replies: 197
- Total: 203
- Guardian Angel
@dan
I know where I was going wrong. I was reading key to symbols and at the top it says they can’t be taken. Silly me .

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
13 December 2015 at 1:55 pm #6151
LondonGirl
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- Total: 1,364
- Guardian Angel
@londongirl
Got to be careful with bad eczema, that it doesn’t get infected. Another reason to bathe with a drop of pure lavender oil before applying creams. Either way, make sure skin is very clean before putting cream on.

Glad to hear you’re feeling a little brighter Dan.

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
13 December 2015 at 10:28 pm #6179
Dan
- Topics: 6
- Replies: 197
- Total: 203
- Guardian Angel
@dan
It is strange how each day feels different. Today I’m so shattered, feel dizzy, shaking and BB slightly low 125/70. At night my left arm was keep getting numb.

I didn’t have easy start, although I wasn’t feeling that great before tx.

I will see how it goes possiblity until 4 weeks, if no UND, I might get Indian/Nepal generics.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
13 December 2015 at 10:45 pm #6182
darbara
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- Replies: 166
- Total: 172
- Guardian Angel
@darbara
personally I think you will be ok. From all I have read YOU being treatment naive F1-F2 should clear it in 4-6 weeks

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
13 December 2015 at 10:49 pm #6183
Dan
- Topics: 6
- Replies: 197
- Total: 203
- Guardian Angel
@dan
Thanks for your support darbara.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
14 December 2015 at 3:06 am #6202
Sirchinenge
- Topics: 7
- Replies: 260
- Total: 267
- Guardian Angel
@sirchinenge
I hope you don’t take this the wrong way I think you’re over thinking this way too much I’ve
never heard of anyone starting a new treatment before the first one stops.

You’re seriously suggesting if you’re not UD at four weeks changing drugs may be the right course of action?

I don’t know anyone professional or layman who would agree with what you’re suggesting.

I’ve read your thread, I think many of your symptoms are nothing to do with Hep C or the treatment
you’re on. I think, you’re spending way too much time thinking about your disease and not allowing
yourself the time to get well……..

I’m gonna go a step further and suggest you should think about finding someone to talk about your anxiety
the way you’re presenting is of concern,I mean that in the kindest possible way.

I’m not trying to be mean or have a go at you I find your posts a little worrying.

PS. I don’t think going to your clinic and withholding you’re on treatment is the best course of action either you’re
attending clinic having bloods done without them knowing you’re on treatment. If you’re on treatment you need to
be honest and tell them. Why lie, what have you too gain ,what do you intend saying when your bloods come back
and have changed? They have a duty of care too you regardless of your choice.

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
14 December 2015 at 3:31 am #6203
Dan
- Topics: 6
- Replies: 197
- Total: 203
- Guardian Angel
@dan
Sirchinege

I take your points and agree that I’m possibly over thinking.

I didn’t lie to the hospital, just decided not to tell them. The reason for that is, when I mentioned generics, the consultant told me that they don’t monitor patients on generics and adviced to go private.Why tell something, if you already got No.

The next appointment to see my consultant is early March in the mean time I am going to see my GP on the 21 st and tell him about my treatment and ask for bloods, which will be at 4 weeks.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
14 December 2015 at 4:26 am #6205
zhuk
- Topics: 5
- Replies: 543
- Total: 548
- Guardian Angel
@zhuk
Hey Dan,

I’m quite sure I’ve read of people still being detected (though very low levels of course) at EOT, but attaining UND after that. I wouldn’t worry in the slightest about not being undetected at the 4 WK mark.

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
14 December 2015 at 4:35 am #6207
Gaj
- Topics: 29
- Replies: 1,402
- Total: 1,431
- Guardian Angel
@gaj
Hi Dan,

I agree with Sirchinenge that changing meds if your viral load isn’t UND at 4 weeks is not the correct decision. Please see the Doc’s post below about when different people attain low viral loads which can take up to 8 weeks in some cases. But also note that even then he is not talking about only UND but also some who will be in the <15 group at that point. In fact I have read in a number of the trials where people have still been showing <15 at EOT and have then gone on to be UND at SVR12 or 24.

http://fixhepc.com/forum/experts-corner/287-viral-load-on-treatment-what-to-expect.html

I also agree that it would help if you have someone you can confide in with your concerns about both your treatment and the other health issues you have. I know from experience that this can be difficult with the stigma attached to hep c but it is important for all of us to share our thoughts and feelings with someone we trust. A close friend or relative perhaps? Or if that is not possible, your GP as you seem to trust him enough to have informed him you are treating with generics? Otherwise, I am sure that there are many of us here including myself who would be happy to Private Chat with you from a laymans POV if there are worries that you don’t wish to discuss in open forum.

How is the sleep going? As I’ve said in a few other threads I believe it is important to sleep at least reasonably well during treatment so if you are still having problems please discuss that with your GP too, and check drug interaction charts if he wants to prescribe something. You don’t want to bomb yourself out each night but at least a few good nights each week until you get use to the meds will help I’m sure.

Hope this helps
G

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
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