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  • 24 December 2015 at 5:26 pm #7250
    Avatar photoNadia
    • Guardian Angel
    • ★★★★★
    @nadia

    Hopefully with the improved sleep the physical improvements will follow, Dan

    Virus not detected from 14.10.2015

    24 December 2015 at 8:14 pm #7254
    Avatar photodarbara
    • Guardian Angel
    • ★★★★★
    @darbara
    Dan wrote:

    Day 22
    Still don’t feel any big physical improvements, apart from sleep.

    I started to feel pain in my calf 3 days ago and it gets worse every day

    Same here but its edema for me. Swollen feet and ankle mostly on the left foot

    Treatment naive
    F 3/4
    Genotype 1 a & b
    V/L 17 MILLION
    Started Harvoni 11th Dec 2015 for 12 weeks
    4 weeks VL UND
    6 WEEKS ALT 32, AST 34
    EOT 03/03 2016 ! UND
    ALT 34, AST 26
    04.04.2016 SVR 4
    26.05.2016 SVR 12
    16.08.2016 SVR 24

    25 December 2015 at 1:37 pm #7273
    Avatar photoEnkel
    • Guardian Angel
    • ★★★★★
    @enkel

    My strange symptoms that I had before treatment are amplified a little bit. Today two weeks in Twinvir.

    Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
    Started Twinvir 12/12/15.
    Two weeks
    ALT 17 at 2 weeks
    Viral Load UND at 2 weeks
    ALT 13.5 at 7 weeks EOT
    ALT 10.5 at 15 weeks EOT
    ALT 13 at 27 weeks EOT, VL UND, Cured

    25 December 2015 at 1:52 pm #7274
    Avatar photodarbara
    • Guardian Angel
    • ★★★★★
    @darbara

    same here I had edema in the left leg and now its in the right leg too. Dryness and itching have been there for 2 years now. Otherwise I sleep better now. Day 15 here of Harvoni.

    Treatment naive
    F 3/4
    Genotype 1 a & b
    V/L 17 MILLION
    Started Harvoni 11th Dec 2015 for 12 weeks
    4 weeks VL UND
    6 WEEKS ALT 32, AST 34
    EOT 03/03 2016 ! UND
    ALT 34, AST 26
    04.04.2016 SVR 4
    26.05.2016 SVR 12
    16.08.2016 SVR 24

    25 December 2015 at 2:33 pm #7277
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    You should see a doctor about the ankle swelling.

    I have a handful of patients who have developed fluid retention on treatment initiation.

    It can be treated with diuretics but should not be ignored. It can progress to ascites.

    Please check in with a doctor.

    YMMV

    25 December 2015 at 4:10 pm #7285
    Avatar photoEnkel
    • Guardian Angel
    • ★★★★★
    @enkel

    Yes Darbara, you should check with a doctor.

    Indeed, Twinvir affected my sleep only the first day, then the sleep has been ok

    Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
    Started Twinvir 12/12/15.
    Two weeks
    ALT 17 at 2 weeks
    Viral Load UND at 2 weeks
    ALT 13.5 at 7 weeks EOT
    ALT 10.5 at 15 weeks EOT
    ALT 13 at 27 weeks EOT, VL UND, Cured

    25 December 2015 at 4:18 pm #7286
    Avatar photodarbara
    • Guardian Angel
    • ★★★★★
    @darbara

    The left leg swelling was before I started Harvoni but now its on the right ankle leg too. Its pitting edema. I will ASAP. Thanks for the advice.

    Treatment naive
    F 3/4
    Genotype 1 a & b
    V/L 17 MILLION
    Started Harvoni 11th Dec 2015 for 12 weeks
    4 weeks VL UND
    6 WEEKS ALT 32, AST 34
    EOT 03/03 2016 ! UND
    ALT 34, AST 26
    04.04.2016 SVR 4
    26.05.2016 SVR 12
    16.08.2016 SVR 24

    25 December 2015 at 7:59 pm #7298
    Avatar photoEnkel
    • Guardian Angel
    • ★★★★★
    @enkel

    darbara,

    do you have the sensation of formication (a sensation like insects crawling over the skin)

    Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
    Started Twinvir 12/12/15.
    Two weeks
    ALT 17 at 2 weeks
    Viral Load UND at 2 weeks
    ALT 13.5 at 7 weeks EOT
    ALT 10.5 at 15 weeks EOT
    ALT 13 at 27 weeks EOT, VL UND, Cured

    25 December 2015 at 9:38 pm #7303
    Avatar photodarbara
    • Guardian Angel
    • ★★★★★
    @darbara

    No I dont

    Treatment naive
    F 3/4
    Genotype 1 a & b
    V/L 17 MILLION
    Started Harvoni 11th Dec 2015 for 12 weeks
    4 weeks VL UND
    6 WEEKS ALT 32, AST 34
    EOT 03/03 2016 ! UND
    ALT 34, AST 26
    04.04.2016 SVR 4
    26.05.2016 SVR 12
    16.08.2016 SVR 24

    27 December 2015 at 1:45 am #7348
    Avatar photoDan
    • Guardian Angel
    • ★★★★★
    @dan

    Merry Christmas to all and a Happy New Year!!!.

    For the past couple of days I’ve had lots of cakes and biscuits. I hope that it won’t have a negative impact bon my tx.

    I wanted to check, why do we need to take the tablets for 12 weeks, if the virus disappears in the blood after 2 weeks?

    Gen 1b, F1-F2. Naive.
    Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
    Starting VL 400000, Alt 49/AST 44
    1 week VL 29, ALT 44/AST 30.
    4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
    7 weeks VL Detected, ALT 28, all other normal
    8 weeks UND, 12 week UND, 24 week SVR UND

    27 December 2015 at 1:52 am #7349
    Avatar photoPaul-Jarman-facebook
    • Guardian Angel
    • ★★★★★
    @paul-jarman-facebook

    We kill off the easy to get to virus in the first few weeks but the reall challenge is knocking the ones out that reside in hard to get to places in our bodies. Scar tissue for instance is hard to get to which is why the longer treatment times for cirhotics and relapsers.

    cheers

    Two time relapser.

    SVR 4 achieved 12/16 at last
    SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

    GT 3 – about 28 yrs with HCV

    27 December 2015 at 2:08 am #7350
    Avatar photoJoy
    • Guardian Angel
    • ★★★★★
    @joy

    Hi Dan, this thread might help:

    http://fixhepc.com/forum/experts-corner/164-resistance-and-treatment-failure-mechanisms.html?limitstart=0

    27 December 2015 at 3:21 am #7353
    Avatar photoDan
    • Guardian Angel
    • ★★★★★
    @dan

    Thanks Paul and Joy.

    Dr Freeman explained it very well. I’ll see what my 4 weekly VL result will show after New Year and might order 4 additional weeks, just in case. I have F1-2 fibroscan score and a bit extra treatment will not hurt.

    Gen 1b, F1-F2. Naive.
    Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
    Starting VL 400000, Alt 49/AST 44
    1 week VL 29, ALT 44/AST 30.
    4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
    7 weeks VL Detected, ALT 28, all other normal
    8 weeks UND, 12 week UND, 24 week SVR UND

    29 December 2015 at 9:16 pm #7494
    Avatar photoDan
    • Guardian Angel
    • ★★★★★
    @dan

    Day 27.
    Went for a blood test today, will get the results next week.

    My dizziness got worse, today spent most of the day on the sofa. The room doesn’t spin around, but when I start to move, I feel like on the rocking boat.

    Gen 1b, F1-F2. Naive.
    Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
    Starting VL 400000, Alt 49/AST 44
    1 week VL 29, ALT 44/AST 30.
    4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
    7 weeks VL Detected, ALT 28, all other normal
    8 weeks UND, 12 week UND, 24 week SVR UND

    29 December 2015 at 11:51 pm #7497
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Hi Dan, Was just reading up on some of my blood test results, My serum sodium is slightly out.

    Anyway, when you get your blood results back, check that one?

    If you have high serum sodium, it can cause dizziness on getting up and is called hypernatremia :

    This can be from :

    Not drinking enough water and therefore – Dehydration
    Eating too much salt
    Some drugs
    Hyperventilation (breathing too fast)
    or a loss of body fluids from prolonged vomiting, diarrhea, sweating or high fevers.

    You may not have any symptoms, unless your blood sodium levels are significantly elevated, but you could get :

    Dizziness when you stand up or change positions (you may be dehydrated).
    Severe sweating or fever; vomiting and diarrhea with markedly elevated sodium levels, if your hypernatremia is due to a loss of body fluids.

    Advise :

    Sodium levels must be corrected carefully. If you have a very high sodium level, your healthcare provider will cautiously correct the levels, to a “safe level.”

    It is important that you stay well hydrated if blood test results show that you have Hypernatremia. Drink two to three quarts of fluid every 24 hours, unless you are instructed otherwise.

    Avoid caffeine and alcohol, as these can cause you to have electrolyte disturbances.

    You may not have Sodium out of balance, but it’s generally handy info anyway I feel .

    Susie

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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